Science
Mechanism of Action
This innovative ingredient functions as a potent signaling peptide, initiating the skin's intrinsic repair mechanisms. It is designed to stimulate the regeneration of mature skin, enhancing its structure and visibly diminishing the appearance of fine lines and wrinkles. The ingredient also contributes to a refined skin complexion and improved elasticity. Leveraging its nicotinoyl component, it is understood to upregulate collagen production in fibroblast cultures, mitigate elevated dermal glycosaminoglycans often associated with photodamage, and augment the synthesis of crucial epidermal proteins such as keratin, filaggrin, and involucrin. Furthermore, it exerts anti-glycation effects, counteracting skin sallowness, while simultaneously boosting cellular energy and impeding cellular senescence.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Formal review by the Cosmetic Ingredient Review (CIR) Expert Panel is pending, and publicly available SCCS or FDA statuses are not established for this specific compound. Paula's Choice has not yet assigned a rating, awaiting further research. However, INCI Beauty reports no adverse penalties across its safety assessments for this ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
NICOTINOYL SH-PENTAPEPTIDE-19 presents a compelling mechanistic profile for comprehensive anti-aging and skin conditioning; however, comprehensive clinical efficacy data and full regulatory safety reviews are presently limited, necessitating further investigation.
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