Science
Mechanism of Action
This precision peptide operates by signaling the skin to activate its natural collagen synthesis processes, thereby enhancing firmness and elasticity. The strategic incorporation of a nicotinoyl group, derived from Vitamin B3, further amplifies its anti-aging benefits and anti-inflammatory properties, promoting skin repair and reducing visible signs of aging.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Clinical evaluations of cosmetic compositions containing nicotinoyl peptide derivatives, formulated within a concentration range of 0.005-1 wt%, demonstrated superior collagen generation, notable anti-inflammatory activities, and significant anti-wrinkle effects. These benefits were observed with minimal cytotoxicity and robust long-term stability of the formulations.
Transparency
Dusting Analysis
Data regarding 'dusting' specific to this ingredient is not available in the provided research.
The Formula
Formulation
Stability
Nicotinoyl peptide derivatives, including this ingredient, exhibit excellent stability, maintaining their efficacy over extended periods during long-term storage within cosmetic formulations.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel announced 'Insufficient Data' for the broader category of 'Pentapeptide Ingredients' in September 2023; however, this assessment was not specific to NICOTINOYL PENTAPEPTIDE-33. General nicotinoyl peptide derivatives are noted for exhibiting little cytotoxicity and low potential for skin stimulation, suggesting a favorable safety profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This ingredient presents as a valuable peptide for advanced skincare, offering strong potential for collagen synthesis and anti-inflammatory action to reduce signs of aging, based on derivative studies.
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References
Sources