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NICOTINOYL HEXAPEPTIDE-45.

Insufficient Data / ANTIOXIDANT, SKIN PROTECTING, UV FILTER

Nicotinoyl Hexapeptide-45 is a distinct compound synthesized from Niacin (Vitamin B3) and Hexapeptide-45. It is theoretically formulated to deliver antioxidant defense, broad skin protection, and UV filtering properties, though specific clinical validation remains to be established.

Antioxidant Skin Protecting UV Filter

Science

This ingredient is hypothesized to exert its effects through multiple pathways: as an antioxidant, it aims to neutralize reactive oxygen species, protecting skin cells from oxidative stress. Its 'skin protecting' and 'UV filter' functions suggest a role in fortifying the skin barrier against environmental aggressors and potentially absorbing or scattering UV radiation, respectively. Chemically, it bridges the bioactive components of Niacin with a specific hexapeptide.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments from major regulatory bodies such as the Cosmetic Ingredient Review (CIR), Scientific Committee on Consumer Safety (SCCS), or FDA have been found for Nicotinoyl Hexapeptide-45. While information exists for the related compound Nicotinoyl Hexapeptide-44 indicating general safety, uncommon side effects, and a low comedogenicity rating (1 out of 5), these attributes are not directly transferable to Nicotinoyl Hexapeptide-45.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Insufficient Data

While Nicotinoyl Hexapeptide-45 presents theoretical benefits as an antioxidant, skin protectant, and UV filter, there is currently insufficient specific clinical efficacy and safety data to definitively assess its performance and suitability in skincare formulations.


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