Science
Mechanism of Action
This ingredient is hypothesized to exert its effects through multiple pathways: as an antioxidant, it aims to neutralize reactive oxygen species, protecting skin cells from oxidative stress. Its 'skin protecting' and 'UV filter' functions suggest a role in fortifying the skin barrier against environmental aggressors and potentially absorbing or scattering UV radiation, respectively. Chemically, it bridges the bioactive components of Niacin with a specific hexapeptide.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
No specific safety assessments from major regulatory bodies such as the Cosmetic Ingredient Review (CIR), Scientific Committee on Consumer Safety (SCCS), or FDA have been found for Nicotinoyl Hexapeptide-45. While information exists for the related compound Nicotinoyl Hexapeptide-44 indicating general safety, uncommon side effects, and a low comedogenicity rating (1 out of 5), these attributes are not directly transferable to Nicotinoyl Hexapeptide-45.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While Nicotinoyl Hexapeptide-45 presents theoretical benefits as an antioxidant, skin protectant, and UV filter, there is currently insufficient specific clinical efficacy and safety data to definitively assess its performance and suitability in skincare formulations.
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