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NICOTINOYL DIPEPTIDE-22.

Valuable / SKIN CONDITIONING

Nicotinoyl Dipeptide-22 is a sophisticated synthetic peptide derivative that merges nicotinic acid (Vitamin B3) with a dipeptide. It acts as a multi-functional skin conditioning agent, expertly targeting concerns from uneven skin tone and hyperpigmentation to signs of aging, while bolstering skin's natural defenses.

Summary

Skin conditioning Brightening Anti-aging Antioxidant Collagen boosting Elasticity enhancing Skin barrier support Anti-inflammatory UV protection (indirect) Hyperpigmentation reduction

Science

Mechanism of Action

This peptide derivative functions by preventing melanocyte deposition and inhibiting cell aging, contributing to a brighter, more even skin tone. Its nicotinamide component, a precursor to vital coenzymes NAD and NADP, is crucial for cellular energy and DNA repair, stimulating collagen production within fibroblasts. It further strengthens the epidermal barrier by enhancing lipid and protein synthesis (keratin, filaggrin, involucrin) and offers anti-glycation benefits to combat skin sallowing. By acting as a molecular messenger, it activates fibroblasts to promote the synthesis of extracellular matrix proteins like collagen and elastin, while also exhibiting anti-inflammatory and UV damage protective properties. It is noted to be effective for skin whitening and melanocyte deposition prevention, particularly in combination with Tranexamoyl Dipeptide-22.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Clinical observations indicate an improvement in skin tone evenness, a reduction in the appearance of dark spots and hyperpigmentation, and the promotion of a more youthful complexion. The ingredient also contributes to enhanced overall skin texture and radiance, while providing protection against UV damage and preventing melanocyte deposition.
  2. 02 Studies highlight its capacity to stimulate collagen synthesis and significantly boost skin elasticity, which aids in reducing the visibility of fine lines and wrinkles. Additionally, it offers antioxidant protection and enhances the skin's moisture retention capabilities.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Nicotinoyl Dipeptide-22 maintains stability under recommended storage conditions. Protection from heat and light is advised. While no specific optimal pH range for stability is provided, it is generally compatible with cosmetic formulations typically ranging between pH 5.00 and 6.00.

Synergies

  • Tranexamoyl Dipeptide-22 (for enhanced skin whitening and prevention of melanocyte deposition)

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Nicotinoyl Dipeptide-22 has not undergone review by CIR, SCCS, or FDA. However, it is generally described as non-toxic and has been dermatologically tested for safe topical application. Adverse reactions are infrequent, though a patch test is always recommended as a precautionary measure. It is noted as an 'Irritant Free' ingredient in products by SkinSAFE.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Nicotinoyl Dipeptide-22 is a valuable active ingredient, offering a wide array of benefits including skin brightening, anti-aging, barrier support, and antioxidant protection, with a low risk of irritation across all skin types.

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