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Moumoujus

NICOTINAMIDE MONONUCLEOTIDE.

Insufficient Data CAS 1094-61-7 / ANTIOXIDANT

Nicotinamide Mononucleotide (NMN) is a potent precursor to NAD+, a critical coenzyme for cellular energy and repair. By replenishing declining NAD+ levels, NMN aims to rejuvenate skin cells, enhancing overall skin health and resilience.

Summary

Antioxidant Skin-Conditioning Anti-aging Anti-inflammatory Hydrating Barrier-support

Science

Mechanism of Action

NMN functions as a direct precursor to Nicotinamide Adenine Dinucleotide (NAD+), a vital coenzyme fundamental for cellular energy metabolism, DNA repair processes, and regeneration. As NAD+ levels diminish with age, NMN supplementation helps restore these critical levels, thereby optimizing cellular metabolism and promoting skin cell rejuvenation. Topically, NMN improves the skin's barrier function, boosts hydration and elasticity, minimizes the appearance of wrinkles, and helps preserve dermal collagen density. It also acts as a powerful antioxidant, neutralizing free radicals and protecting against oxidative stress from environmental aggressors. Furthermore, NMN exhibits anti-inflammatory effects by modulating signaling pathways, which can aid in skin healing, recovery, and potentially alleviate conditions like eczema and acne. Its action also supports the synthesis of hyaluronic acid, elastin, and collagen, contributing to a smoother, firmer, and more youthful complexion, and can assist in reducing hyperpigmentation for an improved skin tone.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

5%

Key findings

  1. 01 Topical application in mice demonstrated attenuation of epidermal thickening, significant improvements in skin hydration and elasticity, reduced wrinkle formation, preservation of dermal collagen density, and enhanced antioxidant defense. It also effectively prevented eczema-like skin damage, lowered reactive oxygen species (ROS) and inflammatory molecules, and elevated natural antioxidant levels.

Transparency

Dusting Analysis

Not commonly dusted

NMN is a well-researched active with a clear mechanism of action and preclinical efficacy, indicating it is not typically used for 'dusting'.

The Formula

Formulation

Solubility
Water
Optimal pH 6 – 7.5
0 7 14

Stability

NMN is highly water-soluble and hydrophilic, exhibiting optimal stability in neutral to slightly acidic conditions within a pH range of 6.0 to 7.5. Degradation is accelerated in highly acidic (pH < 4) or alkaline (pH > 9) environments due to glycosidic bond hydrolysis, primarily driven by water molecules. For optimal stability in formulations, low storage temperatures, appropriate pH adjustment, and reduced water content (e.g., in high-density NMN preparations) are crucial. Encapsulation, such as in liposomes, can further enhance stability and potentially improve skin permeation. It is not shelf-stable under high temperatures or humidity.

Conflicts

  • Oily bases (due to its hydrophilic nature)
  • Highly acidic (pH < 4) environments
  • Highly alkaline (pH > 9) environments

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) currently categorizes NMN with 'insufficient data' for safety assessment in cosmetics. The Scientific Committee on Consumer Safety (SCCS) has not issued a specific opinion on Nicotinamide Mononucleotide. While the FDA has had a complex regulatory stance on NMN as a health supplement, it was confirmed in September 2025 not to be excluded from the definition of a dietary supplement. Notably, China's National Medical Products Administration approved NMN as a new cosmetic ingredient on November 1, 2023. Human oral trials indicate NMN is safe and well-tolerated at doses up to 500 mg without adverse effects or changes in vital signs.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Nicotinamide Mononucleotide shows significant promise in preclinical studies for broad skin benefits, but current human topical safety and efficacy data remain limited, warranting cautious consideration.

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