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NICOTIANA BENTHAMIANA SH-POLYPEPTIDE-15 HEXAPEPTIDE-40.

Valuable / SKIN CONDITIONING

This advanced fusion peptide precisely combines Hexapeptide-40 with a recombinant human peptide bio-engineered from the Nicotiana benthamiana plant. It acts as a biomimetic for human Tissue Inhibitor of Metalloproteinases-2 (TIMP-2), offering targeted action to support skin rejuvenation and structural integrity.

Skin Conditioning Anti-Aging Skin Regeneration Wrinkle Reduction Elasticity Improvement Extracellular Matrix Support

Science

Operating as a biomimetic TIMP-2, this ingredient specifically inhibits Matrix Metalloproteinase-2 (MMP-2), an enzyme implicated in extracellular matrix degradation. Concurrently, it stimulates the production of fibromodulin, a crucial component that enhances the organization and structural stability of the extracellular matrix through optimized collagen binding. Functionally, it acts as a signaling molecule, activating the skin's endogenous repair mechanisms, fostering the regeneration of mature skin, and visibly improving overall complexion and elasticity, resulting in a softer, smoother, and more supple skin feel.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

CIR Status
Not reviewed
Sensitization risk Low

Generally considered safe for topical application in cosmetic formulations. However, specific data regarding its use during pregnancy or breastfeeding is currently unavailable, thus consultation with a healthcare professional is recommended. A preliminary patch test is advisable prior to widespread application to ascertain individual skin sensitivity.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

This biomimetic peptide offers a targeted approach to enhancing skin structure and reducing signs of aging by modulating key enzymatic activities and supporting extracellular matrix integrity.


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