Science
Mechanism of Action
This recombinant human peptide operates by signaling the body to activate the skin's endogenous repair systems. It is believed to stimulate cell regeneration and enhance the synthesis of vital proteins like collagen, elastin, and fibronectin. Additionally, it promotes the proliferation of keratinocytes and fibroblasts, which are crucial for skin renewal. These actions collectively contribute to improved skin firmness, elasticity, texture, and hydration, while also supporting the natural skin barrier and potentially thickening the epidermis.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This compound is typically supplied as a freeze-dried powder, indicating a need for careful formulation to maintain stability in aqueous solutions.
Safety
Safety Profile
While authorized as a cosmetic ingredient, long-term risks for NICOTIANA BENTHAMIANA RH-OLIGOPEPTIDE-1 remain largely unestablished. However, a closely related variant, Nicotiana Benthamiana Hexapeptide-40 sh-Oligopeptide-1, exhibits low hazard scores for cancer, allergies, immunotoxicity, and developmental/reproductive toxicity by EWG, and is deemed 'Irritant Free' by SkinSAFE.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite its theoretical promise as an EGF bioequivalent with broad skin benefits, the clinical efficacy of this ingredient is questionable due to conflicting study outcomes, including an independent trial reporting no benefit, highlighting the need for more robust and unbiased research.
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