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Moumoujus

NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-POLYPEPTIDE-76.

Valuable / SKIN CONDITIONING

This advanced bio-engineered fusion peptide, derived from Nicotiana benthamiana, precisely mimics human Transforming Growth Factor Beta-2 (TGF-β2) to activate the skin's intrinsic repair mechanisms. It delivers broad-spectrum anti-aging benefits, including robust collagen production and refinement of pore size, resulting in a more youthful and resilient complexion.

Summary

Skin conditioning Anti-aging Moisturizing Evens skin tone Enhances skin firmness Improves skin elasticity Stimulates cellular turnover Supports skin regeneration Reduces pore size

Science

Mechanism of Action

Functioning as a sophisticated fusion peptide, NICOTIANA BENTHAMIANA HEXAPEPTIDE-40 SH-POLYPEPTIDE-76 combines hexapeptide-40 with a recombinant human peptide. This human peptide is genetically synthesized by Nicotiana benthamiana to be identical to human TGF-β2, a critical protein regulating cellular growth and differentiation. It acts as a cellular signaling agent, prompting the skin to activate its endogenous repair processes. This activation enhances collagen synthesis, specifically Collagen I, leading to improved skin firmness and elasticity. Furthermore, it stimulates cellular turnover and regeneration, while simultaneously bolstering skin integrity and protection through increased extracellular matrix protein synthesis and epidermal lipid production. The ingredient exhibits activity akin to retinol and retinoic acid in collagen production and offers comprehensive anti-aging benefits.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Reneseed™ (containing this ingredient) demonstrates efficacy comparable to retinol and retinoic acid in stimulating collagen I production. It provides broad-spectrum anti-aging benefits, including notable reductions in pore size.
  2. 02 In a 15% solution (The Ordinary GF 15% Solution, containing this ingredient as 'Growth Factors'), users reported skin feeling 'more plumped', suggesting enhanced volume and density.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally recognized as safe for topical application in cosmetic formulations. While uncommon, potential side effects such as skin irritation, redness, itching, or allergic reactions may occur, therefore a preliminary patch test is recommended. Insufficient data exist regarding its topical use during pregnancy and breastfeeding, hence consultation with a healthcare professional is advised for these populations.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

This advanced bio-engineered peptide offers significant retinol-like anti-aging effects by activating intrinsic repair mechanisms, making it a valuable asset for comprehensive skin rejuvenation and improved skin integrity.

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