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NIACINAMIDOETHYL RETINOATE.

Valuable CAS 1642294-93-6 / BLEACHING

NIACINAMIDOETHYL RETINOATE, also known as NEAR 1, is a patented biomolecule that intelligently fuses Vitamin A (Retinol) and Niacinamide. This innovative combination is engineered to deliver comprehensive retinoid benefits with superior stability, enhanced efficacy, and significantly reduced irritation.

Summary

skin brightening anti-aging improves fine lines and wrinkles evens skin tone reduces appearance of oily skin exfoliation

Science

Mechanism of Action

This novel molecule works by leveraging the synergistic actions of its two components. The Vitamin A portion actively promotes skin cell renewal, leading to visible rejuvenation, reduction of fine lines and wrinkles, and a fresher complexion. Concurrently, the Niacinamide component provides robust brightening properties by inhibiting melanosome transfer, strengthens the skin's natural barrier through increased lipid and ceramide synthesis, and offers anti-inflammatory and sebostatic effects, helping to regulate oil production. Crucially, the Niacinamide also stabilizes the Vitamin A within the molecule, extending its activity and mitigating potential irritation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A clinical study with the first product containing NEAR 1 demonstrated visible improvements in skin tone after a six-week application period. The specific concentration of NIACINAMIDOETHYL RETINOATE within this product was not explicitly stated.

Transparency

Dusting Analysis

Not commonly dusted

As a patented, specifically engineered molecule designed to be an effective and stable Vitamin A technology, NIACINAMIDOETHYL RETINOATE is not typically used at sub-efficacious 'dusting' levels. Its inclusion in formulations implies an intention for active benefit.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Engineered for enhanced stability, the Niacinamide component within the molecule aids in preserving the integrity of the Vitamin A. For optimal stability of the Niacinamide component in a formula, a pH range of 4.0-7.0 (specifically 4.0-6.0 or 5.0-7.0) is often recommended to prevent its conversion to potentially irritating niacin. NIACINAMIDOETHYL RETINOATE has been successfully formulated into light oil bases, such as those containing squalane, to ensure proper dissolution and stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While NIACINAMIDOETHYL RETINOATE as a distinct combined molecule has not undergone specific review by CIR, SCCS, or FDA, its individual constituents have been assessed. The CIR Expert Panel considers Niacinamide and Niacin safe for cosmetic use, with clinical tests showing no stinging up to 10% and no irritation up to 5%. Retinol and Retinyl Palmitate were deemed safe by CIR in 1987 and reaffirmed in 2005. This combined molecule is noted for its low irritation profile, described as significantly less irritating (approximately half) than conventional retinol. One product containing NEAR 1 was found to be hypoallergenic.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

NIACINAMIDOETHYL RETINOATE represents a valuable advancement in retinoid technology, providing effective anti-aging and brightening benefits with a significantly improved stability and tolerability profile, making it suitable for a wide range of skin types, including sensitive.

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