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Moumoujus

NEROLIDOL ISOMERS.

Valuable CAS 7212-44-4 / PERFUMING

Nerolidol isomers are versatile sesquiterpene alcohols known for their ability to enhance skin penetration, allowing for improved absorption of other active ingredients. Additionally, they contribute significant antioxidant, anti-inflammatory, and antimicrobial properties to skincare formulations.

Summary

skin penetration enhancer antimicrobial anti-inflammatory antioxidant fragrance

Science

Mechanism of Action

This ingredient functions as a skin penetration enhancer, facilitating the deeper delivery of co-applied active ingredients by temporarily modulating the lipid structure of the stratum corneum. At a cellular level, Nerolidol exhibits antioxidant activity by upregulating key antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), while simultaneously reducing malondialdehyde (MDA), a recognized marker of oxidative stress. Its anti-inflammatory effects stem from its ability to inhibit the release of proinflammatory cytokines and various inflammatory mediators.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Nerolidol exhibits well-documented mechanisms of action, including skin penetration enhancement and anti-inflammatory properties, suggesting its inclusion is typically for functional benefit rather than solely for marketing claims at sub-efficacious levels.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Nerolidol demonstrates excellent stability across most fragrance applications. Its tertiary alcohol structure provides superior resistance to oxidation compared to primary or secondary alcohols. However, as a terpene, it may undergo polymerization via oxidation pathways under extreme conditions. A key formulation consideration is its limited aqueous solubility, which can restrict its use in water-based systems.

Synergies

  • other active ingredients (due to enhanced skin penetration)

Conflicts

  • aqueous formulations (due to low aqueous solubility)

Safety

Safety Profile

CIR Status
Safe as used
Max tested
1.15%
Sensitization risk Low

While some classifications list Nerolidol as a skin sensitizer Category 1B (H317) and an eye irritant Category 2 (H319), human studies at a 4% concentration demonstrated no irritation or sensitization on skin. It is recognized as Generally Recognized As Safe (GRAS) by the FDA for flavor uses and adheres to EU Regulation 1223/2009, not being among the 26 mandatory declarable allergens.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Nerolidol is a valuable ingredient, offering multifaceted benefits from enhancing the delivery of other actives to providing antioxidant and anti-inflammatory support, with a favorable safety profile at regulated cosmetic concentrations.

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