Science
Mechanism of Action
Nephelium Lappaceum Leaf Extract functions by stimulating the skin's natural production of essential structural proteins such as type I and type V collagen, and fibrillin-1. It significantly activates dermal genes including ELN, FBLN5, COL1A2, P4HA2, P4HA1, and actively inhibits CCN1, thereby improving skin firmness and elasticity. Additionally, it offers powerful antioxidant capabilities, safeguarding existing collagen from degradation and strengthening the epidermal barrier against external damage. Its multifaceted action positions it as a natural retinol alternative, addressing aging signs through similar pathways but with a favorable tolerability profile.
Research
Clinical Evidence
Medium confidence0.03%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This extract is primarily water-soluble or dispersible, often co-formulated with Maltodextrin to enhance miscibility. In scenarios where water solubility is less optimal, propylene glycol may serve as a solvent aid, and citric acid can be utilized for pH buffering.
Safety
Safety Profile
Formal safety assessments by regulatory bodies such as CIR, SCCS, or FDA are not currently available. However, in vitro studies indicate no cytotoxicity at concentrations up to 0.1 mg/mL, and INCIDecoder data suggests a low irritancy profile.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Nephelium Lappaceum Leaf Extract is a valuable ingredient for advanced skincare formulations, providing significant anti-aging benefits through collagen and elastin synthesis, robust antioxidant protection, and acting as a well-tolerated retinol alternative.
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References
Sources