Science
Mechanism of Action
This extract is rich in an array of bioactive compounds, including essential oils, flavonoids, and phenolic acids. Its antioxidant efficacy is primarily attributed to these phenolic compounds and flavonoids, which neutralize free radicals to mitigate oxidative stress. Furthermore, it functions as a humectant, attracting and retaining moisture in the stratum corneum, while also recognized for its hair conditioning attributes.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Demonstrated significant anti-oxidative activity in vitro, exhibiting an IC50 of 134.24 ± 1.42 µg/mL for DPPH radical scavenging and a Ferric Reducing Antioxidant Power (FRAP) value of 1385.15 ± 8.12 µmol/L.
Transparency
Dusting Analysis
There is no available data to suggest this ingredient is commonly used at sub-efficacious concentrations or that a 'dusting threshold' is relevant for its described mechanisms of action.
The Formula
Formulation
Safety
Safety Profile
Acute oral toxicity studies in mice showed no mortality at concentrations up to 5000 mg/kg for aqueous and 70% ethanol extracts, classifying it as practically non-toxic according to OECD 423. While no official CIR, SCCS, or FDA review exists for cosmetic use, independent assessments like SkinSAFE categorize 'Nepeta Sibirica Extract' as free from common irritants and allergens, including parabens, dyes, and fragrance. INCIDecoder also indicates low irritancy. Minor and temporary reduced mobility and sedation were noted in mice at high oral doses.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Nepeta Sibirica Flower/Leaf/Stem Extract is a valuable botanical ingredient, demonstrating confirmed in vitro antioxidant and humectant properties, coupled with a favorable safety profile for sensitive and dry skin.
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References
Sources
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