Science
Mechanism of Action
The blend works synergistically across multiple pathways. Nelumbo Nucifera Leaf extract is a potent antioxidant and anti-inflammatory agent, actively inhibiting melanogenesis by up to 59% in vitro and showing potential chemopreventive effects by modulating DNA methylation and activating the NRF2 pathway. Orostachys Japonica extract contributes antioxidant defense, acts as an antimicrobial agent against gram-positive bacteria and yeast (0.05-0.1% MIC), and functions as a humectant and skin conditioner. Saururus Chinensis extract rounds out the blend with robust anti-inflammatory and antioxidant activities, demonstrated to mitigate atopic dermatitis-like skin lesions by balancing the Th1/Th2 immune response.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In an in-vitro DOPA-oxidase assay, Nelumbo nucifera leaf extract demonstrated significant melanogenesis inhibition, reducing melanin production by 59% at a concentration of 100 µg/ml.
- 02 Further in-vitro studies on murine skin cells indicated Nelumbo nucifera leaf ethanolic extract at 25 µg/mL could downregulate key proteins (DNMT1, DNMT3A, DNMT3B, HDAC3, HDAC8, HDAC4) associated with skin carcinogenesis, suggesting chemopreventive potential.
- 03 A clinical trial involving 21 volunteers reported significant skin whitening effects when Nelumbo nucifera callus extract (HLCE) was delivered in cosmetic formulations, utilizing 5% propanediol as a solvent for the extract.
- 04 Ethanol extracts from Orostachys japonica leaf exhibited minimum inhibitory concentrations (MIC) between 0.05-0.1% against various gram-positive bacteria and yeast in vitro.
- 05 An animal study (NC/Nga mice) showed that oral administration of Saururus chinensis extract effectively inhibited the development of atopic dermatitis-like skin lesions, reducing severity, itching, and inflammatory cell infiltration.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Orostachys japonica leaf extract's antioxidant activity maintains high stability within a pH range of 2-8, with its antimicrobial activity stable from pH 2-10 (except for B. subtilis). Nelumbo nucifera components have been shown to be extractable with both water and various organic solvents, suggesting diverse soluble components.
Safety
Safety Profile
The CIR Expert Panel issued a Tentative Report in March 2025, indicating insufficient data to determine the safety of all 14 Nelumbo nucifera-derived ingredients. No specific CIR, SCCS, or FDA status was found for Orostachys japonica or Saururus chinensis extracts, either individually or as part of this blend, within the provided results.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While individual components demonstrate promising in-vitro and animal efficacy across antioxidant, brightening, anti-inflammatory, and antimicrobial functions, the overall safety profile for the blend, particularly for long-term topical use, requires further comprehensive assessment due to insufficient regulatory data.
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