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Moumoujus

NELUMBO NUCIFERA GERM EXTRACT.

Insufficient Data CAS 85085-51-4 / SKIN CONDITIONING

Nelumbo Nucifera Germ Extract is a botanical active known for its profound cellular rejuvenation capabilities. It works by activating crucial internal processes, aiding in the clearance of cellular debris and enhancing mitochondrial health, while also supporting collagen synthesis for improved skin firmness and a revitalized complexion.

Summary

Anti-aging Collagen Booster Antioxidant Antimicrobial Skin Conditioning Astringent Firming Cellular Renewal

Science

Mechanism of Action

This extract orchestrates cellular rejuvenation by reactivating autophagy, a fundamental process for clearing abnormal proteins and agglutinates. It achieves this by upregulating DAPK1 expression through histone acetylation, subsequently triggering the DAPK1-Beclin1 signaling pathway. This pathway stimulation is key to restoring mitochondrial function and reversing cellular aging phenotypes. Furthermore, it significantly boosts collagen production and enhances fibroblast contractile ability. Beyond its deep cellular action, it provides robust antioxidant protection against free radicals, exhibits antimicrobial properties, and forms a protective barrier to maintain skin hydration. Its astringent tannins also contribute to a refined complexion.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated the ability to clear abnormal proteins and agglutinates by autophagy-mediated restoration of mitochondrial function and cellular aging phenotypes. It also stimulated collagen production and increased contractile ability in three-dimensional cell culture.
  2. 02 Observed rejuvenation of naturally-aged cell functions and appearance, leading to a face-lifting effect, improvement of deep wrinkles, and overall rejuvenation of 'Skin age'.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7
0 7 14

Stability

A water cream formulation containing 4% Nelumbo Nucifera Germ Extract maintained stability for 30 days across various temperature conditions, indicating robust stability within typical cosmetic matrices.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

The CIR Expert Panel has concluded that the available data are insufficient to determine the safety of Nelumbo Nucifera Germ Extract, as well as other Nelumbo Nucifera-derived ingredients, in cosmetic applications. While Nelumbo Nucifera Flower Extract, which shares some characteristics, was previously deemed non-toxic, non-comedogenic, and generally safe for use between 0.1%-5%, these findings do not directly apply to the germ extract. Individual patch testing is strongly advised due to the lack of specific safety data for the germ extract.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Nelumbo Nucifera Germ Extract demonstrates promising mechanisms for cellular rejuvenation and anti-aging in studies, a conclusive safety and optimal concentration profile remains undetermined by regulatory bodies due to insufficient data.

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