Science
Mechanism of Action
This extract operates at a cellular level by initiating autophagy, a process that clears abnormal proteins and restores mitochondrial function, thereby improving cellular aging phenotypes. It achieves this by upregulating DAPK1 expression through histone acetylation, which in turn activates the DAPK1-Beclin1 signaling pathway. Furthermore, it directly enhances collagen production and boosts the contractile ability of skin cells, while also acting as a skin conditioning agent and humectant.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Nelumbo nucifera germ extract rejuvenates aging fibroblasts by autophagy-mediated restoration of mitochondrial function, clearing abnormal proteins, and improving cellular aging phenotypes. It also stimulates collagen production and increases contractile ability in three-dimensional cell culture. No specific concentration was reported for these effects.
- 02 A Nelumbo nucifera *callus* extract (HLCE) demonstrated dose-dependent melanin synthesis inhibitory effects. At 0.025%, melanin inhibition was approximately 20.26% to 30.52%, and at 0.1%, it ranged from 75.80% to 82.18%. It is important to note this data refers to a *callus* extract, not the germ extract.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Nelumbo nucifera germ extract demonstrates excellent water solubility and stability, facilitating its straightforward incorporation into various formulations.
Safety
Safety Profile
The Expert Panel for Cosmetic Ingredient Safety has concluded that available data are insufficient to make a definitive safety determination for Nelumbo Nucifera Germ Extract.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While Nelumbo Nucifera Germ shows promising scientific mechanisms for cellular rejuvenation and collagen synthesis, a conclusive safety determination by the CIR Expert Panel is currently pending due to insufficient available data.
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References
Sources