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Moumoujus

NELUMBO NUCIFERA CALLUS CULTURE EXTRACT.

Insufficient Data CAS 85085-51-4 / ANTIMICROBIAL, ANTIOXIDANT, HUMECTANT

Nelumbo Nucifera Callus Culture Extract, derived from lotus plant cells, is a multi-functional ingredient known for its significant anti-pigmentation and antioxidant properties. It actively hydrates, soothes, and helps protect the skin from environmental stressors, contributing to a more even-toned and healthy complexion.

Summary

Antioxidant Skin-conditioning Humectant Anti-inflammatory Antimicrobial Skin-whitening/Anti-pigmentation

Science

Mechanism of Action

This extract functions comprehensively by inhibiting melanin synthesis, primarily through the suppression of tyrosinase activity and overall melanogenesis, leading to skin brightening. It acts as a potent antioxidant, neutralizing free radicals to prevent oxidative stress and premature aging. Furthermore, it offers humectant benefits, drawing and retaining moisture for enhanced hydration, and possesses both anti-inflammatory and antimicrobial properties that contribute to skin health and clarity.

Research

Clinical Evidence

Medium confidence
Effective range 0.025–0.1%
Optimal

N/A

Key findings

  1. 01 In an in vitro study utilizing B16F1 melanoma cells, a Haman region lotus-derived callus extract demonstrated a dose-dependent inhibition of melanin synthesis: 26.65% at 0.025%, 36.02% at 0.050%, and a substantial 78.89% at 0.100%.
  2. 02 A clinical trial involving 21 volunteers reported significant skin whitening, with a measurable reduction in melanin content observed from the sixth week of administration of a cosmetic cream containing an unspecified concentration of the extract.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

A related Nelumbo nucifera extract in a water cream formulation exhibited stability for 30 days across various temperature conditions. The callus culture extract itself has been formulated using distilled water with 5% propanediol as a solvent.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

The Expert Panel for Cosmetic Ingredient Safety (CIR) determined that currently available data are insufficient to conclude the safety of Nelumbo Nucifera Callus Culture Extract. This determination is primarily due to a lack of 28-day dermal toxicity and UV absorption data. If dermal absorption occurs, further phototoxicity and photosensitization data may be required. While adverse reactions are generally uncommon and the ingredient is rated as a 'non-irritant' with a primary cutaneous irritation index of 0.097, patch testing is recommended.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Insufficient Data

While Nelumbo Nucifera Callus Culture Extract shows promising benefits for pigmentation, hydration, and antioxidant protection, its overall safety rating remains 'insufficient data' by the CIR due to critical data gaps.

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