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Moumoujus

NARDOSTACHYS JATAMANSI EXTRACT.

Avoid / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Nardostachys Jatamansi Extract is a botanical ingredient traditionally noted for its soothing properties, acting as both an antioxidant and anti-inflammatory agent. It is recognized for its potential to reduce oxidative stress and calm skin, while also contributing to improved skin hydration and overall complexion.

Summary

Skin Conditioning Antioxidant Anti-inflammatory Collagen/Elastin Support Moisture Retention Antimicrobial Antifungal

Science

Mechanism of Action

This extract functions by scavenging free radicals, thereby protecting skin from oxidative damage. Its anti-inflammatory capabilities stem from inhibiting pathways such as NF-κB and JAK/STAT in keratinocytes, which helps to alleviate skin redness and irritation. Additionally, it aids in skin conditioning by promoting moisture retention and may support the synthesis of collagen and elastin, potentially improving skin firmness and elasticity. The extract also possesses healing, antimicrobial, and antifungal properties, contributing to overall skin health.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A component of the extract, Cycloolivil, demonstrated anti-inflammatory effects in HaCaT keratinocytes by inhibiting TNF-α/IFN-γ-induced chemokine production through the blocking of NF-κB and JAK/STAT activation.
  2. 02 The extract exhibited concentration-dependent antioxidant activity in vitro, effectively inhibiting DPPH radicals with an IC50 value measured at 60.03 μg/mL.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH 5 – 7
0 7 14

Stability

To maintain optimal stability and potency, the extract should be stored in a cool, dry place, away from direct sunlight.

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Low

Clinical trial data specifically for topical use are limited, and the ingredient has not been reviewed by the Cosmetic Ingredient Review (CIR) panel. Individuals with known hypersensitivity to N. jatamansi should avoid its use. Furthermore, safety during pregnancy and lactation has not been established, therefore usage is advised against during these periods. A significant concern is a study reporting genotoxicity of aqueous and hydroalcoholic extracts at concentrations of 5 mg/mL and 10 mg/mL.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

Despite some promising in-vitro antioxidant and anti-inflammatory activities, Nardostachys Jatamansi Extract is not recommended for precision skincare formulations due to its unreviewed CIR status, lack of comprehensive human clinical safety data, and documented genotoxicity at concentrations potentially relevant for topical application.

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