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NANNOCHLOROPSIS GADITANA EXTRACT.

Valuable / ANTIOXIDANT, SKIN CONDITIONING

Nannochloropsis Gaditana Extract is a potent microalgae-derived ingredient known for its extensive skin protective and rejuvenating properties. Rich in antioxidants and beneficial compounds, it actively combats oxidative stress, promotes hydration, and supports a healthy skin barrier. Its multifaceted action contributes to an overall healthier, more resilient, and youthful complexion.

Summary

Antioxidant Skin-Conditioning Anti-aging Hydration Brightening Anti-inflammatory UV Protection Barrier Support Collagen Boosting

Science

Mechanism of Action

This extract functions primarily as a powerful antioxidant, neutralizing free radicals to prevent oxidative stress and premature aging. It works at a cellular level, mediating oxidative responses and apoptosis, while positively regulating genes like AQP3, Col6A1, and FBN1 to enhance skin texture and hydration. Furthermore, it modulates genes linked to irritation (IL1R), DNA damage (PCNA), and aging (FOXO3), demonstrating anti-melanogenic effects through tyrosinase inhibition, anti-wrinkling benefits by inhibiting elastase and promoting collagen production, and contributing to anti-inflammatory and UV protective actions.

Research

Clinical Evidence

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In vitro studies demonstrate significant ABTS radical scavenging activity, a marker for antioxidant efficacy, with an IC50 of 0.336 mg extract.
  2. 02 Concentration-dependent inhibition of human elastase was observed with an IC50 of 0.23 ± 0.02 mg, indicating potential anti-wrinkling benefits by preserving skin elasticity.
  3. 03 Anti-melanogenic effects were noted through concentration-dependent inhibition of human tyrosinase, with an IC50 of 2.69 ± 0.13 mg, suggesting efficacy in reducing hyperpigmentation.
  4. 04 In human dermal fibroblasts, in vitro concentrations of 408 and 870 μg/ml exhibited skin protection by mediating oxidative responses and apoptosis. These concentrations also upregulated genes crucial for skin texture and hydration (AQP3, Col6A1, FBN1) and modulated genes involved in skin irritation, DNA damage, and aging (IL1R, PCNA, FOXO3).
  5. 05 A broader in vitro study using Nannochloropsis sp. G1-5 extract at concentrations up to 1500 μg/mL confirmed various skin protective functions with low cytotoxicity, including antioxidant, anti-melanogenic, moisturizing, anti-inflammatory, anti-wrinkling, and UV protective activities.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Due to its rich antioxidant content and composition of polar lipids, fatty acids, amino acids, and vitamins, products containing Nannochloropsis Gaditana Extract should ideally be housed in air-tight and light-proof containers to preserve its efficacy and prevent degradation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally considered safe for topical application in cosmetic products, supported by its low irritancy and comedogenicity. Nannochloropsis algae, including Nannochloropsis gaditana, has also been approved by the FDA for human consumption as a novel food ingredient.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Nannochloropsis Gaditana Extract is a valuable multi-functional ingredient that provides broad-spectrum skin protection, rejuvenation, and hydration with a low risk of irritation or comedogenicity.

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