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Moumoujus

N-PALMITOYL SERINOL.

Valuable CAS 126127-31-9 / SKIN PROTECTING

N-Palmitoyl Serinol is a precision skincare active that functions as a natural metabolite, enhancing the skin's inherent ability to produce essential ceramides. By stimulating specific ceramide species, it fortifies the epidermal barrier, improves hydration, and provides significant protection against inflammatory responses and hyperproliferation, particularly beneficial for compromised and sensitive skin types.

Summary

Skin Protecting Barrier Repair Hydrating Anti-inflammatory

Science

Mechanism of Action

This ingredient operates by activating the endocannabinoid receptor CB1 within the epidermis. This activation triggers both de novo ceramide synthesis and sphingomyelin hydrolysis pathways, leading to a notable increase in total ceramide content, with a particular emphasis on very-long-chain ceramides (C22-C26). The enhanced ceramide profile subsequently strengthens the epidermal permeability barrier, optimizes stratum corneum hydration, and effectively modulates inflammation and excessive cell growth associated with various skin disorders, such as atopic dermatitis.

Research

Clinical Evidence

Medium confidence
Effective range 0.5–0.5%
Optimal

0.5%

Transparency

Dusting Analysis

Not commonly dusted

Current research data does not provide sufficient information to determine common dusting practices, specific dusting thresholds, or red flag percentages for N-Palmitoyl Serinol.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

N-Palmitoyl Serinol presents as a crystalline solid with limited solubility, being noted as slightly soluble in Dimethylformamide (DMF). For cosmetic formulations, it typically requires incorporation into oil-based systems and may necessitate specific solubilizing agents (e.g., DMSO, SBE-β-CD in saline). The use of heat and/or sonication can assist in achieving full dissolution and preventing precipitation or phase separation during formulation.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Known also as Neuromide, N-Palmitoyl Serinol is registered with the United States Food and Drug Administration (FDA) as a Type IV Drug Master File. However, specific Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) reports regarding its safety in cosmetic applications are not available. In vitro studies indicated a significant decrease in human epidermal keratinocyte viability at concentrations of 50 μM or higher, suggesting a cautious approach for cellular applications, though a topical maximum concentration for human use has not been established.

Your Skin

Skin Compatibility

No Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

N-Palmitoyl Serinol is a valuable ingredient for advanced skincare, demonstrating significant potential in stimulating ceramide production, reinforcing skin barrier function, and offering anti-inflammatory benefits for dry, sensitive, and compromised skin.

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