Science
Mechanism of Action
This compound primarily inhibits melanogenesis by downregulating the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase, both critical for melanin synthesis. Crucially, N-Nicotinoyl Tyramine does not directly impact the catalytic activity of existing tyrosinase enzymes.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 N-Nicotinoyl Tyramine demonstrated inhibition of melanin production in α-MSH stimulated B16F10 murine melanoma cells, human melanocytes, and a sophisticated three-dimensional human skin model.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
While N-Nicotinoyl Tyramine has not undergone specific safety assessments by organizations such as CIR or SCCS, its safety as a non-skin irritant has been verified through human repeated insult patch tests and neural stem cell morphology assays. No specific FDA cosmetic ingredient status is available; FDA references to 'nicotinoyl' compounds generally pertain to unrelated substances like Picamilon.
Your Skin
Skin Compatibility
Our Assessment
Verdict
N-Nicotinoyl Tyramine presents as a valuable ingredient for targeting hyperpigmentation, with demonstrated efficacy in inhibiting melanin production across various skin models and a verified low irritation potential, making it suitable for all skin types.
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References
Sources