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N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE.

Avoid CAS 84041-77-0 / HAIR DYEING

N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE is a chemical component predominantly utilized in hair coloring products. It serves as both an oxidative and direct hair dye, enabling the formation of stable color complexes within the hair shaft for lasting coloration.

Summary

Hair Dyeing

Science

Mechanism of Action

The primary mechanism of action for this compound is centered around its role in hair dyeing. When incorporated into hair dye formulations, it undergoes oxidation, typically initiated by hydrogen peroxide, to create reactive intermediates. These intermediates then interact with the hair's keratin structure to produce stable, vibrant color. No mechanism of action specifically beneficial for direct skin application has been identified or documented.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

This ingredient's function is strictly as a hair dye, not a dermatologically active compound. Therefore, it is not an ingredient that would be 'dusted' into skincare formulations for any skin-specific benefits.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The compound demonstrates water solubility and exhibits stability under oxidative hair dyeing conditions, showing approximately 98% recovery over 60 minutes in a 3% hydrogen peroxide mixture at pH 9. For optimal storage, it is critical to maintain it in nitrite-free containers to prevent unwanted reactions.

Conflicts

  • Nitrosating agents

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk High

The Scientific Committee on Consumer Safety (SCCS) has deemed N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE safe for hair dye applications, with maximum on-head concentrations of 1.0% for oxidative dyes and 1.5% for non-oxidative dyes. However, it is classified by GHS as causing skin irritation (H315) and serious eye irritation (H319). As a secondary amine, it carries a risk of nitrosation; therefore, formulations must ensure nitrosamine content is below 50 ppb and avoid co-formulation with nitrosating agents. While the Cosmetic Ingredient Review (CIR) Expert Panel concluded that a related compound, N,N-Bis(2-Hydroxyethyl)-p-Phenylenediamine Sulfate, is safe as a hair dye ingredient, this specific compound has not undergone a direct CIR safety review. Studies on related compounds have indicated potential for inducing delayed hypersensitivity in guinea pigs at 3% and strong contact allergic responses at 2%.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy High
Comedogenicity Unknown

Our Assessment

Verdict

Avoid

N,N'-BIS(2-HYDROXYETHYL)-2-NITRO-P-PHENYLENEDIAMINE is a hair dye ingredient with no documented skin benefits and a high risk of skin and eye irritation, rendering it unsuitable for precision skincare formulations.

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