Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

N-HYALURONOYL 5-HYDROXYDOPAMINE.

Insufficient Data / HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

N-HYALURONOYL 5-HYDROXYDOPAMINE is an advanced conjugate combining hyaluronic acid with 5-hydroxydopamine, engineered to deliver dopamine's beneficial functionalities to the skin while significantly improving stability and minimizing the inherent toxicity of free dopamine.

Summary

Hydrating Regenerative Anti-inflammatory Cell Proliferation Support Antioxidant (via reduced autoxidation)

Science

Mechanism of Action

This innovative compound operates by synergistically leveraging the distinct properties of its two constituent parts. The 5-hydroxydopamine moiety provides dopamine-mimetic actions, supporting various cellular processes, but critically, with substantially reduced autoxidation and cytotoxicity compared to native dopamine. Simultaneously, the hyaluronic acid component ensures robust hydration, stimulates cellular proliferation, aids in tissue regeneration, and helps to quell inflammatory responses. The hyaluronic acid also serves to stabilize the dopamine derivative, thereby slowing its degradation and enhancing its sustained efficacy within the epidermal layers.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In an in vitro study, the compound demonstrated functional characteristics akin to dopamine at a concentration of 0.062 µM, notably exhibiting minimal autoxidation and cytotoxicity.
  2. 02 Formulated into a hydrogel, dopamine-methacrylated hyaluronic acid was found to be nontoxic and biocompatible. It effectively promoted cell proliferation in vitro, facilitated skin defect regeneration in vivo, and inhibited inflammatory responses within wounds.

Transparency

Dusting Analysis

Not commonly dusted

No data is currently available to suggest that N-HYALURONOYL 5-HYDROXYDOPAMINE is prone to dusting concerns.

The Formula

Formulation

Solubility
Water
Optimal pH 5.5 – 5.5
0 7 14

Stability

The optimal pH for the synthesis of dopamine-modified hyaluronic acid is 5.5. The conjugated compound demonstrates significantly improved stability against autoxidation compared to free dopamine, suggesting enhanced longevity and performance in formulations.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

While there is no specific CIR, SCCS, or FDA safety assessment for N-HYALURONOYL 5-HYDROXYDOPAMINE in cosmetic applications, studies consistently describe it as nontoxic and biocompatible, with minimal cytotoxicity and autoxidation. General hyaluronates are considered safe for cosmetic use up to 2% concentration by the CIR.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Although N-HYALURONOYL 5-HYDROXYDOPAMINE exhibits compelling regenerative, hydrating, and anti-inflammatory properties with a favorable safety profile in biological research, further dedicated clinical studies are essential to fully ascertain its efficacy and optimal application within precision cosmetic formulations.

Related

Similar Ingredients

Finding similar ingredients…