Science
Mechanism of Action
This ingredient primarily functions by scavenging free radicals and significantly reducing intracellular reactive oxygen species (ROS), thereby shielding cells from oxidative stress. It exerts anti-inflammatory effects by neutralizing pro-inflammatory chemokines, specifically CCL17 and CCL22, and inhibiting key enzymes in the arachidonic acid pathway such as COX-2 and 5-LOX. Additionally, it demonstrates anti-apoptotic properties by increasing anti-apoptotic factors (Bcl-2) and decreasing pro-apoptotic factors (Bax), and may contribute to maintaining skin matrix integrity through the suppression of certain matrix metalloproteinases (MMP3/13) and ADAMTS enzymes.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The compound exhibits light sensitivity, requiring protection from light during storage. Stock solutions are stable for 6 months at -80°C or 1 month at -20°C. Its low water solubility, measured at 198.1 mg/L at 25°C, indicates that specialized formulation techniques or solubilizers are likely necessary for effective incorporation into aqueous systems.
Safety
Safety Profile
No specific safety assessments by the Cosmetic Ingredient Review (CIR) or Scientific Committee on Consumer Safety (SCCS) have been identified. Based on ECHA C&L Inventory data from one reporting company, PubChem lists GHS classifications indicating it may cause skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Despite promising in-vitro antioxidant and anti-inflammatory activities, N-Feruloyl Serotonin presents significant formulation challenges due to its low solubility and stability, coupled with a high potential for skin irritation based on GHS classifications, warranting careful consideration for topical applications.
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References
Sources