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Moumoujus

N-COUMAROYL SEROTONIN.

Valuable CAS 68573-24-0 / SKIN PROTECTING

N-Coumaroyl Serotonin is a bioactive compound with notable antioxidant and anti-inflammatory properties. It actively protects skin cells from oxidative stress, calms inflammation, and supports processes crucial for maintaining skin elasticity and firmness, making it a promising ingredient for advanced skincare.

Summary

antioxidant anti-inflammatory cell-communicating ingredient promotes skin elasticity supports skin firmness collagen synthesis booster

Science

Mechanism of Action

This ingredient functions as a potent antioxidant, counteracting cell death, caspase-3 activation, and excess mitochondrial superoxide induced by high glucose. It exhibits anti-inflammatory effects by inhibiting NF-κB activation and down-regulating proinflammatory cytokine mRNA in monocytes. Furthermore, it stimulates fibroblast proliferation, promotes vascular smooth muscle cell relaxation, and attenuates cartilage degradation by suppressing matrix metalloproteinase (MMP3/13) and ADAMTS expression, collectively supporting skin health and structural integrity.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In human blood monocytes, N-Coumaroyl Serotonin at concentrations of 50-200 µM significantly reduced the activity of proinflammatory cytokines (TNF, IL-1, and IL-6) without inducing cytotoxicity.
  2. 02 Studies in rat models demonstrated that 10-100 µM N-Coumaroyl Serotonin relaxed femoral arteries, inhibited an increase in cytosolic free Ca(2+) in vascular smooth muscle cells (VSMCs), and reduced PDGF-BB-evoked proliferation and migration of VSMCs in a concentration-dependent manner.
  3. 03 In vivo studies on mice and rabbits revealed that N-Coumaroyl Serotonin ameliorated atherosclerosis, leading to a reduction in lesion area.

Transparency

Dusting Analysis

Not commonly dusted

Based on its multi-functional mechanisms and reported in vitro effective concentrations, N-Coumaroyl Serotonin does not appear to be a commonly dusted ingredient. Its broad activity suggests benefits beyond minimal inclusion.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

For optimal stability, N-(p-Coumaroyl) serotonin should be stored at -20°C as a powder or between 2-8°C when tightly sealed for up to 24 months. Its solubility in DMSO can be compromised by moisture; therefore, fresh DMSO is recommended for reconstitution.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments by CIR, SCCS, or FDA for cosmetic applications were found. However, zebrafish toxicity testing demonstrated zero mortality at a high concentration of 1 mM, indicating a potentially favorable safety profile in that model.

Your Skin

Skin Compatibility

Yes Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

N-Coumaroyl Serotonin is a valuable ingredient, demonstrating potent antioxidant and anti-inflammatory effects alongside properties that support skin elasticity and firmness, making it highly beneficial for targeted skincare formulations.

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