Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

N-ACETYLSALICYLOYL PHYTOSPHINGOSINE.

Valuable / SKIN CONDITIONING, SKIN PROTECTING

N-Acetylsalicyloyl Phytosphingosine is a skin-identical ceramide derivative designed to fortify the skin's natural defenses. It effectively addresses signs of aging, mitigates inflammatory responses, and significantly enhances the integrity of the skin barrier.

Summary

Anti-aging Wrinkle Reduction Skin Barrier Support Anti-inflammatory Soothing Collagen Boosting ECM Reinforcement Photodamage Repair Skin-identical Ingredient

Science

Mechanism of Action

This advanced ingredient functions by emulating the skin's endogenous phytosphingosine, a crucial component of ceramides. It stimulates the skin's inherent production of vital extracellular matrix proteins, including procollagen-I and fibrillin-1, while concurrently inhibiting detrimental matrix metalloproteases (MMP-1) by downregulating activator protein-1 transcription factor activity, akin to retinoic acid. Its anti-inflammatory properties diminish redness and sensitivity, further supported by its promotion of lipid synthesis and keratinocyte differentiation for a robust skin barrier.

Research

Clinical Evidence

High confidence
Effective range 0.05–0.2%
Optimal

N/A

Key findings

  1. 01 At concentrations ranging from 0.05% to 0.2%, clinical observations confirm a reduction in the visible appearance of fine lines and wrinkles, accompanied by skin calming effects that diminish redness and sensitivity.
  2. 02 Studies indicate that 0.05% and 0.2% concentrations significantly increase the deposition of fibrillin-1 and procollagen-I, and reduce matrix metalloproteases (MMP-1) in photoaged volunteers. A 4-week clinical study further demonstrated clear reductions in wrinkle depth and improvements in skin smoothness and roughness.
  3. 03 Within the 0.05% to 0.2% range, this ingredient has been shown to repair photodamaged skin, reinforce the dermal-epidermal junction, smooth skin's appearance by reducing wrinkles, alleviate symptoms of inflamed skin, and enhance skin barrier function.

Transparency

Dusting Analysis

Not commonly dusted

Specific data regarding 'dusting' practices or thresholds for this ingredient are not available in the provided research. It is typically formulated within clinically studied effective percentages.

The Formula

Formulation

Solubility
Oil
Optimal pH 6 – 8
0 7 14

Stability

Optimal stability and skin compatibility for topical applications are observed in a neutral pH range of 6.0 to 8.0. Acidic pH environments (pH < 6.0) can enhance stability through protonation of the amino group, which also improves solubility in polar environments, though overall aqueous solubility remains limited due to its lipophilic alkyl chain. Alkaline conditions (pH > 8.0) may lead to decreased stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

Direct safety assessments by regulatory bodies such as CIR, SCCS, or FDA for N-ACETYLSALICYLOYL PHYTOSPHINGOSINE are not currently available. However, its parent molecule, Phytosphingosine, is generally considered safe for topical cosmetic use and is well-tolerated by most skin types.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

N-Acetylsalicyloyl Phytosphingosine is a valuable ingredient, clinically proven to reduce visible signs of aging, calm inflamed skin, and significantly strengthen the skin's protective barrier at concentrations between 0.05% and 0.2%.

Related

Similar Ingredients

Finding similar ingredients…