Science
Mechanism of Action
This ingredient is a synthetic lipopeptide, originating from the tripeptide Glycyl-L-Histidyl-L-Lysine (GHK) conjugated with a myristoyl group. This lipophilic modification significantly improves its ability to penetrate the stratum corneum. As a signal peptide, its primary mechanism involves signaling fibroblasts to increase the synthesis of collagen and other extracellular matrix (ECM) components within the dermis. This intricate process is largely mediated through the Transforming Growth Factor-β (TGF-β) signaling pathway, resulting in improved skin structure and integrity. It also acts as a skin-conditioning agent.
Research
Clinical Evidence
Insufficient-data confidenceN/A
Transparency
Dusting Analysis
Myristoyl Tripeptide-1 is typically used at very low concentrations, generally less than 10 ppm (0.001%). This indicates its potency, and formulations adhering to this range are considered appropriate for achieving its intended effects, thus minimizing concerns about 'dusting' below an effective threshold.
The Formula
Formulation
Stability
The myristoyl group is crucial for enhancing the peptide's lipophilicity and subsequent penetration. However, peptides can be prone to degradation and loss of efficacy during storage. Advanced delivery systems may be necessary to overcome challenges related to its solubility and stability, as the hydrophobic myristoyl chain can influence these characteristics while promoting cellular uptake.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has evaluated Myristoyl Tripeptide-1, along with a group of related peptides, and concluded its safety in current cosmetic uses and concentrations. Typical use concentrations are specified as less than 10 ppm. No specific SCCS or FDA restrictions were identified.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Myristoyl Tripeptide-1 is a valuable lipopeptide, engineered for enhanced skin penetration and recognized for its ability to stimulate collagen and ECM production, thereby improving skin firmness and reducing the appearance of aging signs, with a strong safety profile at precise, low concentrations.
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