Science
Mechanism of Action
Functioning as a signaling peptide, Myristoyl Tetrapeptide-4 orchestrates specific biological responses within cells. It stimulates the expression of keratin genes, leading to increased keratin synthesis that strengthens hair follicles and promotes the growth of thicker, longer hair strands. In the skin, it activates the development of dermal papilla cells and signals skin cells to boost the production of collagen and fibronectin, which are vital for maintaining skin’s firmness, elasticity, and smooth texture, thus diminishing the appearance of fine lines and wrinkles. Furthermore, it supports the extracellular matrix and facilitates wound healing and skin repair.
Research
Clinical Evidence
Medium confidence0.05%
Transparency
Dusting Analysis
Insufficient data to determine dusting potential.
The Formula
Formulation
Stability
Stock solutions should be precisely aliquoted and stored at -80°C for up to 6 months or -20°C for 1 month in sealed containers, away from moisture, to prevent inactivation from repeated freeze-thaw cycles.
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel concluded that Myristoyl Pentapeptide-4 (often synonymous with Myristoyl Tetrapeptide-4), along with other related pentapeptides, is safe for use in cosmetics. While some sources continue to cite a 0.05% concentration for various applications, the CIR clarified that a previously reported 0.05% for Myristoyl Pentapeptide-4 was for an experimental product. Corrected maximum reported concentrations for *related* pentapeptides include 0.0035% in hair conditioners and 0.012% in face and neck preparations, underscoring the importance of formulation-specific concentration limits.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Myristoyl Tetrapeptide-4 is a valuable signaling peptide that actively supports skin regeneration, firmness, and elasticity, while also promoting stronger, denser hair growth, and is considered safe for cosmetic applications.
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