Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle

MYRISTOYL PENTAPEPTIDE-8.

Valuable CAS - / SKIN CONDITIONING

Myristoyl Pentapeptide-8 is an advanced synthetic lipopeptide engineered to revitalize skin by strengthening microcirculation and enhancing cellular adhesion. It effectively targets signs of aging, particularly around the delicate eye area, promoting improved skin resilience, hydration, and a smoother complexion.

Collagen Boosting Anti-Aging Microcirculation Enhancement Dark Circle Reduction Eye Bag Reduction Skin Firming Hydration Improvement Wrinkle Reduction Skin Regeneration Capillary Strengthening Skin Conditioning

Science

This synthetic lipopeptide functions by mimicking the activity of natural cell-adhesion proteins, contributing to a perceptibly smoother, healthier, and more resilient skin appearance. It actively upregulates fibroblast growth factor and vascular endothelial cells, crucial for fortifying capillary strength and minimizing blood leakage and pooling, thereby preventing the formation of dark circles. By enhancing dermal cell adhesion and stimulating the production of structural proteins like collagen and keratin, it effectively reduces the appearance of wrinkles, boosts skin hydration, and improves overall softness. The peptide further improves microvessel integrity, optimizes capillary microcirculation, and aids in decongestion. As a collagen booster, it facilitates cell regeneration, repairs damaged skin, slows skin aging, firms the skin, and refines fine lines. It can also inhibit angiotensin-converting enzyme and enhance lymphatic circulation around the eyes, promoting fluid drainage to reduce edema (eye bags) and dark circles. The attached myristoyl group, a fatty acid, is strategically designed to improve skin penetration and stability, increasing its hydrophobicity and affinity for the skin's lipid barrier, which anchors the peptide at cell membranes and lipid domains. This lipidation also boosts its resistance to enzymatic degradation and extends its residence time within the stratum corneum and follicular/epidermal compartments.


Research

High confidence
Effective range 0.005–0.05%
Optimal

0.005%

Key findings

  1. 01 This concentration is recommended for increasing capillary strength, significantly reducing blood leakage and pooling, preventing dark circles, and upregulating both fibroblast growth factor and vascular endothelial cells. Clinical observations also indicate improvements in skin wrinkles, hydration, and softness.

Transparency

Not commonly dusted

Specific data regarding the 'dusting' phenomenon for Myristoyl Pentapeptide-8 is not available in the provided research, therefore no indication of common dusting practices or thresholds is present.


The Formula

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The myristoyl fatty acid attachment is integral to enhancing the peptide's stability and its affinity for the skin's lipid barrier. This structural modification improves its resistance to enzymatic degradation and prolongs its residence time within skin compartments. It demonstrates solubility in water and 1% acetic acid.


Safety

CIR Status
Not reviewed
Sensitization risk Low

Myristoyl Pentapeptide-8 is reported to be free of heavy metals and shows no evidence of skin or eye irritation. SkinSAFE classifies this ingredient as 'Irritant Free', 'Teen SAFE', 'Fragrance Free', and 'Paraben Free' across various categories, indicating a robust safety profile, even for sensitive skin. It is important to note that while the Cosmetic Ingredient Review (CIR) has not specifically assessed Myristoyl Pentapeptide-8, related peptides such as Myristoyl Pentapeptide-4, Palmitoyl Pentapeptide-4, and Pentapeptide-4 have been concluded as safe for use in cosmetics.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

Myristoyl Pentapeptide-8 is a valuable lipopeptide that significantly contributes to anti-aging formulations by strengthening capillaries, enhancing microcirculation, boosting collagen, and improving overall skin resilience and hydration.


Related

Finding similar ingredients…