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Moumoujus

MYRISTOYL NONAPEPTIDE-2.

Valuable / SKIN CONDITIONING

Myristoyl Nonapeptide-2, drawing on research for its analogous compound Myristoyl Nonapeptide-3 (Retinopeptide 189), is a sophisticated biomimetic lipo-peptide designed to replicate the anti-aging benefits of retinol. It precisely targets key dermal processes to foster skin renewal and a more youthful complexion without inducing irritation.

Summary

Anti-aging Cell-communicating ingredient Collagen booster Skin renewal Enhances hydration Improves skin barrier

Science

Mechanism of Action

This synthetic lipo-peptide acts as a cell-communicating ingredient, mimicking the biological activity of retinol to stimulate skin regeneration. Its mechanism involves significantly boosting collagen type I production, accelerating cell turnover and dermal cell proliferation, and enhancing overall collagen synthesis. Additionally, it increases hyaluronic acid production and strengthens the skin barrier, leading to improved moisture retention, a smoother texture, and a reduction in the appearance of fine lines and wrinkles.

Research

Clinical Evidence

Medium confidence
Effective range 5–10%
Optimal

10%

Key findings

  1. 01 In ex-vivo human skin explants, a 10% cream containing Myristoyl Nonapeptide-3 significantly increased collagen-1 production by 43%, a remarkable effect comparable to that observed with 0.1% retinoic acid.
  2. 02 In ex-vivo human skin explants, a 5% cream of Myristoyl Nonapeptide-3 was shown to increase epidermal cellular layers, directly indicating an enhancement in cell turnover rates.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

While a specific optimal pH range for Myristoyl Nonapeptide-3 was not identified, peptides generally require careful consideration of pH to maintain their activity and stability within formulations.

Conflicts

  • Direct acids
  • Direct Vitamin C

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Myristoyl Nonapeptide-3 is generally considered safe for topical cosmetic application, exhibiting a low irritancy profile. However, it has not undergone specific safety assessments by the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS). Data regarding its topical usage during pregnancy and breastfeeding are currently insufficient, therefore, consultation with a healthcare professional is advised for individuals in these categories.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Myristoyl Nonapeptide-2 (based on efficacy data for Myristoyl Nonapeptide-3) is a valuable anti-aging peptide, mimicking retinol's profound effects on collagen synthesis and cell turnover to visibly rejuvenate the skin, all while maintaining a low risk of irritation across all skin types.

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