Science
Mechanism of Action
This lipo-peptide operates by acting as a cell-communicating signal, directly stimulating the expression of various keratin genes, including Keratin 3, 19, and key hair keratins (HB1, HB2, HB4, HB5). This action promotes the formation of new hair follicle cells by encouraging the secretion of specific growth factors. Beyond its pro-keratin effects, Myristoyl Hexapeptide-16 also exhibits moisture-retaining properties, anti-aging benefits through enhanced skin resilience, and anti-inflammatory characteristics that contribute to a calmer skin appearance.
Research
Clinical Evidence
High confidence5%
Transparency
Dusting Analysis
Effective concentrations for Myristoyl Hexapeptide-16 are well-defined, with 0.3% demonstrating benefits for scalp health and optimal eyelash efficacy observed around 5% of a peptide blend. Notably, in vitro research indicates that concentrations exceeding 1% may suppress FGF-7 expression, potentially diminishing desired outcomes.
The Formula
Formulation
Stability
This ingredient should be incorporated into formulations at temperatures below 40°C. For long-term stability, storage in sealed containers at 2-8°C is recommended, with -20°C for extended periods, protected from light. While it is water-soluble, its myristic acid attachment makes it a lipo-peptide, enhancing bioavailability. Excessive alcohol content (>10%) can denature its lipid tail, impairing its efficacy. Optimal delivery is achieved via caprylic/capric triglyceride or squalane-based emulsions, which support transdermal transport.
Conflicts
- High alcohol concentrations (>10%)
Safety
Safety Profile
Myristoyl Hexapeptide-16 itself has not undergone specific review by the CIR, SCCS, or FDA. However, peptide ingredients are generally considered safe, as their amino acid components are naturally occurring. Test data on related amino acids has not raised concerns regarding skin irritation or sensitization. A functional upper limit is suggested by in vitro data, indicating that concentrations above 1% may paradoxically suppress FGF-7 expression, potentially reducing efficacy rather than enhancing it.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Myristoyl Hexapeptide-16 is a valuable signal peptide, demonstrating robust efficacy in stimulating keratin production and promoting hair and eyelash growth, while also offering significant benefits for skin resilience and hydration.
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