Science
Mechanism of Action
This extract exerts anti-inflammatory effects primarily through its key phytochemical, myrislignan, which effectively downregulates the expression of pro-inflammatory enzymes such as COX-2 and iNOS by suppressing the NF-kB signaling pathway. As an antioxidant, it actively neutralizes free radicals, including ABTS radicals, preventing oxidative stress. Furthermore, components within its essential oil demonstrate antimicrobial, antibacterial, and antifungal activities, likely by disrupting the structural integrity of microbial cell membranes due to their hydrophobic nature.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Studies on Myristica fragrans essential oil at concentrations of 0.2%, 0.5%, and 1% effectively suppressed the growth of bacteria such as P. multocida and E. coli, demonstrating significant antibacterial activity.
- 02 The essential oil exhibited substantial antifungal activity, showing zones of inhibition against various fungi at precise concentrations: 125 µg/mL for Aspergillus niger, Trichophyton rubrum, and Penicillium chrysogenum, and 62.5 µg/mL for Candida tropicalis and Aspergillus flavus.
- 03 An ethanolic extract derived from nutmeg seed demonstrated robust antioxidant capacity with an IC50 value of 4.6 ± 15 mg/L via the DPPH assay.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Due to the presence of essential oil components, the extract may be susceptible to oxidation, particularly when exposed to air. Acidic conditions can accelerate this oxidative degradation, potentially altering its aroma and efficacy.
Safety
Safety Profile
A specific CIR safety assessment for 'MYRISTICA FRAGRANS FRUIT EXTRACT' is not available, nor is an SCCS assessment. While essential oils from some citrus fruits are GRAS for food, this does not directly translate to cosmetic safety for Myristica fragrans fruit extract. However, INCI Beauty reports 'No penalty' across all categories for this ingredient in cosmetic formulations, and some suppliers list it for cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Myristica Fragrans Fruit Extract is a valuable botanical with demonstrated anti-inflammatory, antioxidant, and antimicrobial potential, though direct clinical efficacy data for the specific fruit extract in skincare is less extensive than for its essential oil or seed extract counterparts.
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