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MYRISTAMINE OXIDE.

Valuable CAS 3332-27-2 / ANTISTATIC, CLEANSING, HAIR CONDITIONING, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING, SURFACTANT - FOAM BOOSTING, SURFACTANT - HYDROTROPE

Myristamine Oxide is a mild, zwitterionic surfactant recognized for its gentle yet effective cleansing, foam-boosting, and conditioning properties. Its unique amphiphilic structure enables it to expertly emulsify and lift impurities, making it a versatile component in precision skincare formulations.

Summary

Surfactant/Cleansing Emulsifying Antistatic Foam Boosting Hair Conditioning Hydrotrope

Science

Mechanism of Action

Functioning as a zwitterionic surfactant, Myristamine Oxide features both polar and non-polar components, allowing it to significantly reduce surface tension and efficiently blend immiscible substances like oil and water. On the skin, it actively encapsulates and lifts dirt, sebum, and other impurities, promoting a refreshed and thoroughly cleansed complexion. Beyond its primary cleansing function, it effectively enhances and stabilizes foam, contributing to a rich lather, and provides conditioning benefits for both skin and hair. Emerging data also suggests mild antimicrobial activity against common bacterial strains.

Research

Clinical Evidence

Medium confidence
Effective range ≤5%
Optimal

5%

Key findings

  1. 01 Studies indicate that Myristamine Oxide is safe, non-toxic, and mild for most skin types, including sensitive skin, at concentrations up to 5% (SpecialChem).
  2. 02 When utilized at concentrations between 5% and 20%, it serves effectively as a primary cleansing agent, emulsifier, and foam stabilizer in diverse personal care products (Ennore India Chemicals).

Transparency

Dusting Analysis

Not commonly dusted

As a liquid surfactant primarily valued for its cleansing and emulsifying capabilities, Myristamine Oxide is not associated with 'dusting' or leaving particulate residue in formulations.

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 10
0 7 14

Stability

Myristamine Oxide demonstrates robust stability across a wide pH range, specifically from approximately 3 to 10. Its zwitterionic structure enables it to resist hydrolysis under acidic, alkaline, and oxidative conditions, ensuring consistent performance. The ingredient's charge state is pH-dependent, existing predominantly in its protonated cationic form below a pKa of approximately 4.0, and transitioning to its neutral zwitterionic state at higher pH levels.

Conflicts

  • When Myristamine Oxide is protonated at lower pH values, combining it with anionic surfactants can lead to precipitation due to strong electrostatic interactions, particularly at intermediate surfactant ratios.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

Myristamine Oxide is generally considered safe and non-toxic for topical application, exhibiting a very low potential for irritation in formulated products, especially at concentrations up to 5%. While the raw, concentrated form carries classifications for skin and serious eye irritation (PubChem GHS), the EPA Safer Chemical program has verified it as a chemical of low concern in finished products. A preliminary patch test is recommended for individuals with highly reactive skin before initial product use. The Cosmetic Ingredient Review (CIR) Expert Panel has not yet published a specific safety assessment for Myristamine Oxide.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Myristamine Oxide is a valuable zwitterionic surfactant, offering gentle yet effective cleansing, robust foam stabilization, and conditioning benefits across all skin types with a low risk of irritation.

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