Science
Mechanism of Action
This extract primarily functions through robust antioxidant activity, facilitated by its rich content of flavonoids and phenolics, which act as effective free radical scavengers. It exerts anti-inflammatory effects by intervening in various pathways, including the inhibition of COX-1, COX-2, 5-LOX, and HYA enzymes, as well as by potentially reducing levels of key inflammatory mediators such as histamine, bradykinin, vasodilatation factors, and prostaglandins. Furthermore, it demonstrates mast cell stabilizing properties, contributing to its soothing and protective benefits against skin irritation and stress.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
There is no available information regarding common dusting practices, specific dusting thresholds, or red-flag percentages for Myrica Nagi Bark Extract in cosmetic formulations within the provided research.
The Formula
Formulation
Stability
Optimal pH ranges for stability in cosmetic formulations have not been identified in the research data. While one study mentioned biosorption efficiency at pH 4.0, this pertained to heavy metal binding rather than the stability of the ingredient itself in a cosmetic context.
Safety
Safety Profile
Myrica Nagi Bark Extract has not undergone formal safety review by CIR, SCCS, or FDA for cosmetic applications. Acute oral toxicity studies indicate a low acute toxicity profile, with LD50 values exceeding 2000 mg/kg for ethanolic extracts and 1000 mg/kg for ethyl-acetate and water extracts in mice. Traditionally, it is recognized as safe for use in Ayurvedic and Unani medicine. Specific data on topical sensitization or irritation in human cosmetic use is not detailed.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Myrica Nagi Bark Extract is a valuable botanical ingredient for precision skincare, demonstrating significant antioxidant and anti-inflammatory actions through in vitro and animal studies, warranting further investigation for topical human applications.
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