Science
Mechanism of Action
This extract operates via a multi-pronged approach to enhance skin health. It exhibits potent antioxidant activity by neutralizing free radicals and enhancing the skin's reducing power, thereby safeguarding cellular integrity. Its anti-inflammatory action is primarily driven by the inhibition of key enzymes such as 5-LOX (IC50: 11.26 µg/mL) and hyaluronidase (IC50: 21.61 µg/mL), alongside the suppression of inflammatory signaling cascades including TNF-α, IL-6, COX-2, and NF-κB. Furthermore, it demonstrates antibacterial properties against common pathogens like Staphylococcus aureus and Pseudomonas aeruginosa, and offers antiallergic effects by moderating histamine release and mast cell degranulation. The extract also actively supports and accelerates the wound healing process.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated anti-inflammatory activity through significant inhibition of 5-LOX (in vitro aqueous extract).
- 02 Showed anti-inflammatory effects via inhibition of hyaluronidase (in vitro aqueous extract).
- 03 Exhibited strong radical scavenging and reducing power in antioxidant assays (DPPH, ABTS, FRAP) with various extracts, particularly aqueous extract.
- 04 Facilitated wound healing in treated animals, leading to increased tensile strength, faster wound contraction, and reduced epithelization time (topical ointment from aqueous bark extract).
- 05 Showed anti-allergic activity in Swiss albino mice (stem bark extract).
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The active phenolic compounds within Myrica Esculenta Bark Extract exhibit high solubility and stability in polar solvents such as water and ethanol, facilitating its incorporation into aqueous cosmetic formulations.
Safety
Safety Profile
Comprehensive safety assessments for topical cosmetic use by regulatory bodies like CIR, SCCS, or FDA are not readily available. While reports on side effects are sparse, rare allergic reactions (e.g., skin rashes, itching) have been noted from large internal quantities. Animal toxicity studies have provided internal LD50 values, but these do not directly translate to topical cosmetic safety.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Myrica Esculenta Bark Extract is a valuable botanical ingredient, demonstrating significant antioxidant and anti-inflammatory benefits, alongside potential for wound healing and anti-allergic properties, pending more comprehensive human topical safety data.
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References
Sources