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Moumoujus

MYRICA CERIFERA BARK EXTRACT.

Insufficient Data CAS 84929-34-0 / ASTRINGENT

Derived from the bark of the wax myrtle tree, Myrica Cerifera Bark Extract is a botanical active renowned for its multifaceted benefits, including potent antioxidant, anti-inflammatory, and antimicrobial properties. It aids in preserving skin's integrity and promoting a clearer, more resilient complexion.

Summary

Antioxidant Anti-glycation Soothing Anti-inflammatory Astringent Toning Stimulating Cleansing Antimicrobial Antibacterial Antifungal

Science

Mechanism of Action

This extract functions as a powerful antioxidant by neutralizing free radicals, thereby mitigating oxidative damage and preventing accelerated skin aging. It exhibits anti-glycation effects by impeding sugar molecule binding to vital skin proteins like collagen and elastin, thus helping to maintain skin's natural resilience and smooth texture. Furthermore, it possesses soothing and anti-inflammatory properties, capable of disrupting pathways associated with acne-related inflammation. Its tannin content contributes to its astringent, toning, stimulating, and cleansing characteristics. The extract also demonstrates antimicrobial and antibacterial efficacy, inhibiting bacterial proliferation, including Staphylococcus epidermidis and Staphylococcus aureus, and offers antifungal benefits.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Myricanol, a constituent of Myrica cerifera, demonstrated dose-dependent inhibition of A549 lung cancer cell growth through apoptosis induction in an in vitro setting. This study did not focus on human skin applications.
  2. 02 An aqueous ethanol extract from the bark of Myrica rubra, a related species, exhibited in vitro testosterone 5-alpha-reductase inhibitory activity and in vivo anti-androgenic effects in castrated Syrian hamsters (flank organ growth) and testosterone-treated C57Black/6CrSlc mice (hair regrowth). No specific effective concentration for human topical application was provided.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 6.5
0 7 14

Stability

Optimal stability is observed within a pH range of 4.0 to 6.5 at 25°C. For preservation of integrity, the extract should be stored in a cool, dry, and light-protected environment. It is commonly formulated as an aqueous-glycerin solution, often preserved with phenoxyethanol.

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Moderate

Formal safety assessments by organizations such as CIR, SCCS, or FDA specifically for cosmetic application of Myrica Cerifera Bark Extract are currently unavailable. The extract contains tannins, which may contribute to irritation, and there have been reports of topical allergic reactions, including skin rashes, itching, or swelling, in some individuals. Internal consumption of high doses may induce mineralcorticoid side effects and potential liver toxicity. Caution is advised for internal use during pregnancy and lactation due to potential mineralcorticoid and carcinogenic activity.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While demonstrating promising in vitro antioxidant, anti-glycation, anti-inflammatory, and antimicrobial mechanisms, specific human skin clinical efficacy data with defined concentrations are insufficient for a conclusive rating, and potential for irritation exists.

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