Science
Mechanism of Action
This extract functions as a powerful antioxidant, attributed to its high concentration of vitamin C, polyphenols, flavonoids, and anthocyanins. It actively neutralizes free radicals, reduces oxidative stress, and upregulates the Nrf2 signaling pathway, crucial for cellular defense mechanisms. Its anti-inflammatory action involves modulating inflammatory pathways, including NF-κB, and limiting the production of pro-inflammatory cytokines such as COX-2, TNF-α, and IL-6. Additionally, it exhibits anti-allergic effects by inhibiting histamine H1 and H4 receptors, histidine decarboxylase, decreasing histamine release, and regulating calcium/NFAT signaling. The extract also contributes to skin hydration, elasticity, regeneration, and supports collagen synthesis.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Prevented reactive oxygen species (ROS) generation and upregulated the Nrf2 signaling pathway in high glucose-induced human keratinocytes, demonstrating significant antioxidant efficacy.
- 02 Notably decreased β-hexosaminidase release in A23187-induced RBL-2H3 cells, indicating a potent anti-allergic effect by inhibiting histamine H1/H4 receptors and histidine decarboxylase.
- 03 Prevented ROS generation and upregulated Nrf2 and NQO1 expression 2.14- and 3.9-fold respectively, compared to dexamethasone in high glucose-induced human keratinocytes, further confirming antioxidant benefits.
- 04 A 70% hydroalcoholic extract exhibited high antioxidant capacity in DPPH scavenging activity.
Transparency
Dusting Analysis
Myrciaria Dubia Fruit Extract is typically incorporated into liquid or emulsion formulations for its active benefits and is not commonly associated with 'dusting' concerns.
The Formula
Formulation
Stability
The extract is highly water-soluble due to its rich content of vitamin C, organic acids, and anthocyanins. It exhibits optimal stability within an acidic to mildly acidic pH range of 2.0 to 5.0, consistent with its natural pH around 2.53. However, its significant vitamin C content makes it highly susceptible to oxidation, necessitating airless or highly air-restrictive packaging to preserve its integrity during formulation and storage.
Safety
Safety Profile
Myrciaria Dubia Fruit Extract has not undergone specific review by the Cosmetic Ingredient Review (CIR) Expert Panel. However, it is generally regarded as 'Physiologically acceptable' for topical application, with no reported toxicity, intolerance, or allergic reactions. Third-party assessments by SkinSAFE categorize it as 'Irritant Free,' and EWG Skin Deep rates it 'LOW' for allergies and immunotoxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Myrciaria Dubia Fruit Extract is a valuable ingredient, offering comprehensive antioxidant, anti-inflammatory, and anti-allergic benefits with high skin compatibility, making it suitable for a wide range of precision skincare applications.
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