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Moumoujus

MYCOSPORINE GLYCINE.

Valuable CAS 65318-21-0 / ANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, LIGHT STABILIZER, SKIN PROTECTING

Mycosporine Glycine is a naturally derived, multifunctional amino acid known for its robust defense mechanisms against environmental stressors. It primarily acts as a molecular sunscreen, effectively absorbing UV radiation, while also serving as a potent antioxidant and displaying anti-inflammatory and anti-aging properties.

Summary

UV Absorber Antioxidant Anti-inflammatory Skin Regeneration Support Anti-aging Photoprotective Radical Scavenger Collagenase Inhibitor Glycation Inhibitor

Science

Mechanism of Action

Mycosporine Glycine operates as a comprehensive skin protectant. It functions as a molecular sunscreen by efficiently absorbing both UV-A and UV-B radiation, subsequently dissipating this energy as heat to mitigate ultraviolet-induced cellular damage. Beyond UV protection, it demonstrates potent antioxidant capabilities, actively neutralizing reactive oxygen species such as singlet oxygen and hydroxyl radicals, and inhibiting lipid peroxidation. The compound also exhibits anti-inflammatory effects by repressing the expression of iNOS and COX-2, and for Mycosporine-2-glycine, inhibiting the NF-κB pathway. Furthermore, it supports skin vitality by promoting the proliferation of normal human skin fibroblasts and offers anti-aging benefits through the inhibition of protein glycation and collagenase activity, while also stabilizing cellular redox homeostasis.

Research

Clinical Evidence

High confidence
Effective range 24–30000%
Optimal

N/A

Key findings

  1. 01 Demonstrated strong photoprotective activity, safeguarding human lung fibroblasts from UV-induced apoptosis.
  2. 02 Stimulated the proliferation of normal human skin fibroblasts by approximately 35-40%.
  3. 03 Moderately inhibited phosphatidylcholine peroxidation in a concentration-dependent manner.
  4. 04 Exhibited significant radical scavenging ability in a DPPH assay.
  5. 05 Inhibited glycation-dependent cross-linking of proteins and showed pronounced collagenase inhibition.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Mycosporine Glycine exhibits high resistance to varying pH conditions for up to 24 hours. While generally stable across a wide range of temperatures, exposure to 80 °C for 3 hours leads to its conversion into β-diketone (6-deoxygadusol) and glycine.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

While mycosporine-like amino acids (MAAs) are generally recognized as natural and biocompatible, and some related MAAs have undergone safety assessments, MYCOSPORINE GLYCINE specifically lacks a review status from CIR, SCCS, or FDA. Notably, Mycosporine-2-glycine has been observed to show no cytotoxic effects on human skin fibroblasts at concentrations up to 200 µM.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Mycosporine Glycine is a highly valuable ingredient, offering broad-spectrum photoprotection, powerful antioxidant action, and significant anti-aging benefits for comprehensive skin health and resilience.

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