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Moumoujus

MURRAYA EXOTICA LEAF EXTRACT.

Valuable CAS - / ANTIOXIDANT, ORAL CARE, SKIN CONDITIONING

Murraya Exotica Leaf Extract, derived from the leaves of the Murraya exotica plant, is rich in bioactive compounds. This extract demonstrates significant antioxidant activity through free radical scavenging and offers beneficial skin-conditioning properties.

Summary

antioxidant skin-conditioning anti-inflammatory antimicrobial

Science

Mechanism of Action

The extract's mechanism of action is attributed to its diverse phytochemical profile, including flavonoids, alkaloids, and essential oils. These compounds primarily function as potent antioxidants, effectively neutralizing free radicals generated by environmental stressors like pollution and UV radiation, thereby protecting skin cells from oxidative damage. The extract also contributes to enhanced skin appearance and texture, promoting a softer, smoother, and more hydrated feel. Historically, it has been recognized for its anti-inflammatory and antimicrobial effects.

Research

Clinical Evidence

Medium confidence
Effective range 1 µg/mL–100 µg/mL%
Optimal

N/A

Key findings

  1. 01 Demonstrated significant antioxidant activity with an IC50 of 1.25 µg/ml in DPPH assays for methanol leaf extracts and 0.245 mg/mL for purified total flavonoids.
  2. 02 In vitro studies showed a 76% wound healing rate at 10 µg/mL on MDA-MB-231 cancer cells.
  3. 03 In vitro research indicated a decline in tumor cell adhesion rates to 64% at 1 µg/mL on MDA-MB-231 cells.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

No specific optimal pH range for final cosmetic formulation stability has been definitively established. The extract can be obtained using solvents such as ethanol or water, containing compounds soluble in both (22.73% in water, 17.37% in ethanol). Essential oils within the plant typically exhibit lower water solubility.

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Low

While generally exhibiting low irritancy potential according to INCIDecoder, a patch test is advised prior to widespread use to mitigate risks of individual sensitivities such as skin irritation, redness, or itching. Comprehensive data on dermal toxicity and maximum safe concentrations are not fully determined. Information regarding its topical safety during pregnancy and breastfeeding is insufficient; therefore, consultation with a healthcare professional is recommended for these individuals.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Murraya Exotica Leaf Extract is a valuable ingredient, demonstrating significant in vitro antioxidant and skin-conditioning benefits with low irritancy and comedogenicity, suitable for most skin types, though further human clinical and regulatory safety data would enhance its profile.

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