Science
Mechanism of Action
This extract operates through several key pathways to enhance skin health. It functions as a potent antioxidant by neutralizing free radicals, thereby protecting skin cells from oxidative stress and preventing premature aging. Its anti-inflammatory properties are crucial for soothing irritated or reddened skin, reducing sensitivity, and strengthening the skin's natural protective barrier, which can help calm conditions like acne and rosacea. Morus Nigra Leaf Extract also targets hyperpigmentation and promotes a brighter complexion by inhibiting tyrosinase, the enzyme responsible for melanin synthesis, with constituents like mulberroside A playing a notable role. Furthermore, it aids in anti-aging by safeguarding skin cells, supporting collagen production, and reducing the appearance of fine lines and wrinkles. The extract also exhibits natural antifungal and antibacterial qualities.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Demonstrated over 90% inhibition of tyrosinase activity (IC50 values from 5.00 µg/mL to 8.49 µg/mL), indicating potent skin brightening and anti-hyperpigmentation effects.
- 02 An ethanol extract at 27.1 mg/mL showed significant in vitro and in vivo antioxidant activity, confirming its ability to protect against free radical damage.
- 03 Exhibited antibacterial effectiveness by forming inhibition zones against Pseudomonas sp. at concentrations of 60% and 100% in controlled tests.
Transparency
Dusting Analysis
Based on the available clinical data detailing specific biological activities at defined concentrations, Morus Nigra Leaf Extract appears to be incorporated for its active benefits rather than as a 'dusting' ingredient.
The Formula
Formulation
Stability
Emulsions formulated with Morus Nigra Leaf Extract exhibited good stability in terms of pH and viscosity for a minimum of 90 days when stored at 4°C, 20°C, and 37°C. The extract may impart a green color to formulations due to its natural pigment content. Active compounds are generally stable at low temperatures and acidic pH (below 5) but are sensitive to temperatures exceeding 80°C, light, and oxygen; refrigeration can aid in preserving optimal stability.
Safety
Safety Profile
Morus Nigra Leaf Extract is generally considered safe for cosmetic use, demonstrating no cytotoxicity on murine melanomas, human keratinocytes, or mouse fibroblasts at concentrations effective for tyrosinase inhibition. While typically well-tolerated, individuals with sensitive skin should perform patch tests, as allergic reactions such as rashes, itching, or redness may occur. It is important to distinguish this from *Morus alba* leaf extract, for which a GRAS notice for food use was withdrawn by the FDA due to insufficient data, a status not directly applicable to *Morus nigra* in cosmetic applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Morus Nigra Leaf Extract is a valuable botanical ingredient offering comprehensive benefits including potent antioxidant protection, effective skin brightening through tyrosinase inhibition, and significant anti-inflammatory and anti-aging properties, making it suitable for a wide range of skin concerns and types.
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