Science
Mechanism of Action
This extract primarily functions by inhibiting melanogenesis, the biochemical pathway responsible for melanin production in the skin, notably through tyrosinase inhibition. Its inherent stilbenoids provide robust antioxidant defense against free radicals and impart soothing, anti-inflammatory benefits, safeguarding the skin from environmental damage.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 NADES (Natural Deep Eutectic Solvent) extracts of Morus alba callus demonstrated anti-melanogenesis activity comparable to methanol extracts in B16-F10 melanoma cells, with no observed irritation on reconstructed human epidermis (RhE).
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Stilbenoids within Morus alba callus extracts, particularly when prepared with a choline chloride-glycerol NADES, exhibit stability for at least six months at 4 °C, with resveratrol being an exception. General Morus Alba extract readily dissolves in water, alcohol, and glycerol but is insoluble in oil. Formulations should consider potential challenges with organic solvent extracts, which may impact consumer experience or ingredient compatibility.
Safety
Safety Profile
While specific safety assessments by regulatory bodies such as CIR, SCCS, or FDA for Morus Alba Callus Extract are currently unavailable, studies utilizing NADES extracts have shown no irritation on reconstructed human epidermis. Morus Alba extracts in general are considered safe for cosmetic use with a high safety profile. A patch test is advisable for individuals with known skin sensitivities.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Morus Alba Callus Extract is a valuable ingredient for its scientifically supported anti-melanogenesis, antioxidant, and anti-inflammatory properties, making it highly suitable for brightening and protective skincare formulations across all skin types.
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References
Sources