Science
Mechanism of Action
This extract primarily modulates melanogenesis by directly inhibiting tyrosinase, the rate-limiting enzyme in melanin production, and subsequently reducing intracellular melanin levels. Its efficacy is attributed to a rich profile of stilbenoids, including mulberroside F, which also confer significant antioxidant and anti-inflammatory properties, protecting the skin from oxidative stress and inflammation-induced pigmentation.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
Clinical data indicates measurable efficacy at specific concentrations (e.g., 0.1% for anti-melanogenesis, 5 mg/mL for tyrosinase inhibition), suggesting it is used with intent and not typically at negligible 'dusting' levels.
The Formula
Formulation
Stability
Stilbenoids within the callus extract, particularly when prepared with a choline chloride-glycerol mixture (Ch1G2), remained stable for six months when stored at 4 °C. However, the stability of specific compounds like resveratrol may vary. To enhance overall stability of the stilbenoid profile, formulators should consider incorporating additional stabilizers, such as antioxidants and photoprotective agents.
Safety
Safety Profile
A 50% w/v Morus Alba Callus Culture Extract, extracted with a natural deep eutectic solvent, showed no irritation on reconstructed human epidermis, maintaining cell viability at 82.36%. This performance aligns with OECD safety guidelines, categorizing it as safe. General Morus Alba Root Extract is broadly considered safe for cosmetic use.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Morus Alba Callus Culture Extract is a valuable active for precision skincare, demonstrating clear in-vitro efficacy in inhibiting melanin synthesis and offering antioxidant benefits with a favorable safety profile across all skin types.
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References
Sources