Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

MORINDA OFFICINALIS ROOT EXTRACT.

Valuable / ANTIOXIDANT, SKIN CONDITIONING

Morinda Officinalis Root Extract is a botanical active prized for its significant antioxidant and anti-inflammatory properties. It works to neutralize harmful free radicals and modulate inflammatory responses, offering substantial benefits for various skin concerns.

Summary

Antioxidant Anti-inflammatory Soothing Anti-aging Immunoregulatory

Science

Mechanism of Action

This extract effectively combats oxidative stress by neutralizing free radicals, thereby reducing cellular damage. Its robust anti-inflammatory action is achieved through the inhibition of key inflammatory cytokines (e.g., TNF-α, IL-17, IL-6, IL-8), inducible Nitric Oxide Synthase (iNOS), and Cyclo-oxygenase (COX-2), alongside the down-regulation of NF-κB activation. In specific contexts like atopic dermatitis, it modulates the MALAT1/miR-590-5p/CCR7 axis to inhibit cellular proliferation and inflammation. These multifaceted actions contribute to its potential anti-aging, moisturizing, and soothing effects on the skin.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Monotropeins, components isolated from Morinda officinalis root, demonstrated anti-inflammatory and antinociceptive activities, effectively reducing acute paw edema in animal models at dosages of 20 and 30 mg/kg.
  2. 02 Morinda officinalis root extract (MORE) and its hairy root extract (MOHRE), at concentrations of 50, 100, and 200 µg/mL, dose-dependently increased the apoptosis of T lymphocytes in vitro and in vivo, and attenuated symptoms of colitis in mice, indicating notable anti-inflammatory and immunoregulatory effects.
  3. 03 An extract of Morinda officinalis remarkably reduced DNCB-induced atopic dermatitis lesions and associated symptoms in mouse models, including decreases in epidermal and dermal thickness, mast cell infiltration, and inflammatory cytokine secretion.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Morinda Officinalis Root Extract is generally considered safe in traditional use. Acute oral toxicity studies in mice showed no obvious toxic reactions or mortality up to 5000 mg/kg BW, with polysaccharides from the root deemed safe at up to 100 mg/kg BW over 30 days. While overall well-tolerated, excessive oral consumption has been associated with mild gastrointestinal disturbances, and rare instances of allergic reactions, such as skin rashes, itching, or swelling, have been reported.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Morinda Officinalis Root Extract is a valuable ingredient, particularly for sensitive and dry skin, demonstrating strong potential for calming inflammation and providing antioxidant protection based on robust animal and in-vitro data.

Related

Similar Ingredients

Finding similar ingredients…