Science
Mechanism of Action
Monochoria Hastata extracts exhibit antioxidant activity primarily through their high content of phenolic compounds and flavonoids, which effectively scavenge free radicals. Its anti-inflammatory effects are mediated by regulating key inflammatory pathways, involving interactions with proteins such as COX, LOX, and IKBα. The antibacterial action is attributed to flavonoids disrupting bacterial membranes and specific fatty acids (e.g., dodecanoic acid, tridecanoic acid methyl ester) inhibiting bacterial fatty acid synthesis.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 Ethanolic extracts of M. hastata leaves showed dose-dependent inhibition in an acetic acid-induced writhing test in mice, achieving 34% inhibition at 200 mg/kg bw and 54% inhibition at 400 mg/kg bw.
- 02 Methanol extract of M. hastata leaf demonstrated OH radical scavenging activity with an IC50 of 0.97 mg/ml. Methanolic leaf extracts showed significant antioxidant capacity in DPPH (IC50 6.1 ± 0.24 μg/ml) and ABTS (IC50 7.4 ± 0.18 μg/ml) free radical scavenging assays.
- 03 An ethyl acetate extract from M. hastata aerial parts exhibited antibacterial activity against various Gram-positive and Gram-negative bacterial strains at 100 mg/ml, with zone inhibition diameters ranging from 7.0 ± 0.3 to 16.5 ± 0.8 mm.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The presence of bioactive compounds with varying solubilities in different extracts (e.g., ethyl acetate, methanol) suggests a stable profile for various components. The strong antibacterial activity observed in fatty acid-rich ethyl acetate extract implies stability of the oil-soluble components.
Safety
Safety Profile
No official safety evaluations by CIR, SCCS, or FDA have been conducted for Monochoria Hastata oil or its extracts. In silico analysis predicted that isolated compounds from the extract were neither carcinogenic nor toxic in Ames tests. However, a study on the aerial parts highlighted arsenic content exceeding permissible limits, emphasizing the critical need for meticulous sourcing and processing to ensure safety in cosmetic applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While Monochoria Hastata extracts demonstrate promising in-vitro and animal anti-inflammatory, antioxidant, and antibacterial properties, a lack of specific human topical efficacy and safety data for the oil form, coupled with a reported concern regarding arsenic levels in raw plant material, necessitates further research for definitive skincare integration.
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References
Sources