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Moumoujus

MOMORDICA GROSVENORII FRUIT JUICE.

Valuable CAS - / HUMECTANT, SOLVENT

MOMORDICA GROSVENORII FRUIT JUICE, also recognized as Monk Fruit Extract, is a natural botanical extract offering comprehensive benefits for skin health. It provides significant antioxidant and anti-inflammatory actions, concurrently enhancing skin hydration and bolstering the skin's natural barrier function. This ingredient is particularly beneficial for soothing and supporting sensitive or compromised skin types.

Summary

Antioxidant Soothing Moisturizer Anti-inflammatory Skin Barrier Support

Science

Mechanism of Action

This ingredient functions through several key pathways to optimize skin health. It acts as a potent antioxidant, actively preventing oxidative stress and thereby shielding skin cells from environmental damage, which may contribute to anti-aging by reducing the appearance of fine lines and promoting collagen synthesis. Its anti-inflammatory capabilities are crucial for calming skin, reducing symptoms such as redness, irritation, and inflammation associated with conditions like acne, achieved by attenuating allergic skin responses and inhibiting histamine release from mast cells. Furthermore, MOMORDICA GROSVENORII FRUIT JUICE supports the skin's ability to attract and retain moisture, maintaining hydration and smoothness. A notable benefit includes the improvement of the skin barrier by enhancing the expression of critical barrier-associated proteins, specifically SIRT1, filaggrin, and claudin-1.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 In a murine model, oral administration of Siraitia grosvenorii residual extract demonstrated significant improvements in atopic dermatitis-like skin lesions, evidenced by reduced serum immunoglobulin E levels and inhibited inflammatory responses, while enhancing skin barrier proteins including SIRT1, filaggrin, and claudin-1.
  2. 02 Studies on TNF-α/IFN-γ-induced human keratinocytes indicated that the extract inhibited the phosphorylation of mitogen-activated protein kinases and decreased the expression of filaggrin and chemokine proteins.
  3. 03 Research further showed inhibitory effects of Momordica grosvenori extracts on 12-O-tetradecanoylphorbol 13-acetate-induced skin inflammation and tumor promotion in mouse skin.
  4. 04 The extract also demonstrated direct inhibition of histamine in mast cells, contributing to its anti-inflammatory profile.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The U.S. FDA has granted Siraitia grosvenorii Swingle fruit extract GRAS (Generally Recognized As Safe) status for use as a sweetener in food. However, the European Food Safety Authority (EFSA) noted that in vitro toxicity data was not sufficiently informative to evaluate the genotoxic potential of microbial metabolites and raised concerns regarding effects on the testes observed in a 90-day study utilizing a monk fruit extract (52% mogroside V). Conversely, a reproductive and developmental screening study in rats at 1,200 mg mogroside V/kg body weight per day revealed no adverse effects on parental, reproductive, or developmental toxicity.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

MOMORDICA GROSVENORII FRUIT JUICE is a valuable botanical extract offering substantial antioxidant, anti-inflammatory, and skin barrier-enhancing benefits, making it a promising ingredient for diverse skin types, particularly sensitive and compromised skin.

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