Science
Mechanism of Action
This botanical extract functions as a depigmenting agent by precisely inhibiting tyrosinase, a key enzyme in melanin synthesis. This action is attributed to compounds like hydroquinone derivatives, such as harounoside, effectively reducing the appearance of freckles, brown spots, and chloasma. Its anti-aging efficacy stems from a potential influence on procollagen synthesis, leading to improved skin firmness, elasticity, and a reduction in wrinkle depth. Additionally, a diverse array of phytochemicals, including alkaloids, flavonoids, and tannins, confer broad-spectrum antimicrobial and antifungal properties, making it effective against common skin pathogens.
Research
Clinical Evidence
Medium confidence0.1%
Key findings
- 01 Demonstrated 45% inhibition of tyrosinase activity.
- 02 Achieved 99.5% inhibition of tyrosinase activity, indicating strong depigmenting potential.
- 03 Applied 3 times/day for 7 days, led to a pronounced decrease and complete disappearance of dermal mycosis spots with no observed adverse effects.
Transparency
Dusting Analysis
Mitracarpus Scaber Extract demonstrates notable efficacy for depigmentation at low concentrations. In vitro studies show 45% tyrosinase inhibition at 0.0125% and 99.5% inhibition at 0.1%. Therefore, concentrations below 0.01% might be considered questionable for depigmenting claims, though general skin conditioning benefits could still be present.
The Formula
Formulation
Stability
The extract's quality can be compromised by drying and storage, as the active compound harounoside may be absent in dried material. Furthermore, phenolic constituents are susceptible to auto-oxidation upon oxygen exposure, potentially leading to the formation of insoluble polymers.
Safety
Safety Profile
No specific safety assessments by CIR, SCCS, or FDA are available. The Good Scents Company reports no GHS classification or oral/dermal/inhalation toxicity. A human pilot study utilizing a 5% extract in an ointment demonstrated no unwanted effects, suggesting good tolerability at this concentration for short-term use. Patent data indicates a preferred usage range in finished products between 0.5% and 10% (w/w).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Mitracarpus Scaber Extract is a valuable botanical ingredient offering robust depigmenting efficacy demonstrated in vitro, coupled with promising anti-aging and confirmed antimicrobial properties, making it a versatile addition for targeted skin concerns.
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References
Sources