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Moumoujus

MIRABILIS JALAPA EXTRACT.

Valuable CAS 91722-88-2 / SKIN CONDITIONING, SKIN PROTECTING

Mirabilis Jalapa Extract, derived from the "Four O'Clock flower," is a multifaceted botanical ingredient. It excels in calming sensitive and reactive skin while simultaneously delivering significant anti-aging, antioxidant, and skin barrier-strengthening benefits.

Summary

Skin conditioning Skin protecting Soothing Anti-aging Antioxidant Skin brightening Barrier strengthening Antimicrobial Astringent Emollient

Science

Mechanism of Action

This botanical extract functions by significantly reducing the overproduction of Nerve Growth Factor (NGF) and inhibiting the TRPV1 receptor, both implicated in heightened skin sensitivity and reactivity, thereby delivering a notable calming effect. It actively supports skin structure by promoting epidermal thickening and enhancing the stratum corneum's barrier function, crucial for resilience. Furthermore, it exhibits potent antioxidant activity through free radical scavenging and contributes to anti-aging by inhibiting elastase activity and up-regulating specific anti-aging protein expression, which in turn aids in regulating dermal collagen production. Its capacity to promote BMP-1 production from dermal fibroblasts underscores its role in maintaining collagen functionality. Additionally, it can inhibit tyrosinase activity, suggesting an ability to modulate melanin synthesis, and provides antimicrobial, astringent, emollient, and general skin-protecting actions.

Research

Clinical Evidence

Medium confidence
Effective range 0.00015–1.5%
Optimal

N/A

Key findings

  1. 01 At a concentration of 0.05 g/L, the extract significantly promotes the production of Bone Morphogenetic Protein-1 (BMP-1) from dermal fibroblasts, indicating its potential to bolster collagen functionality.
  2. 02 Clinical application within a concentration range of 0.00015% to 1.5% (dry residue) has demonstrated its ability to reduce the overproduction of Nerve Growth Factor (NGF) and TRPV1 receptor activity. This action leads to epidermal thickening and improved barrier function of the stratum corneum, proving highly beneficial for sensitive skin treatment.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

For optimal incorporation, Mirabilis Jalapa Extract can be solubilized using physiologically acceptable agents such as ethanol, propanol, isopropanol, propylene glycol, glycerol, butylene glycol, 1,3 propane diol, or polyethylene glycol, either individually or in combination. Emulsifiers or powder supports may also facilitate its integration into formulations.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has not specifically reviewed Mirabilis Jalapa Extract. However, studies on specific fractions, such as the ethanol extract and alkaloid fraction of Mirabilis jalapa flowers, have demonstrated low cytotoxicity (IC50 > 30 ppm) in an iron deficiency Hepatocarcinoma (HepG2) cell model. It is generally considered safe for cosmetic use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Mirabilis Jalapa Extract is a valuable ingredient, effectively soothing sensitive skin and offering significant anti-aging, antioxidant, and barrier-enhancing benefits for a wide range of skin types.

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