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Moumoujus

MIRABILIS JALAPA CALLUS POWDER.

Insufficient Data / SKIN CONDITIONING

Mirabilis Jalapa Callus Powder, derived from the 'four o'clock flower', is a multi-functional ingredient designed to enhance skin resilience. It works by actively reducing skin sensitivity through neural pathway modulation, fortifying the epidermal barrier, and delivering antioxidant and anti-inflammatory benefits, making it particularly beneficial for reactive or compromised skin types.

Summary

Skin Protecting Sensitivity Reduction Barrier Strengthening Antioxidant Anti-inflammatory Melanin Production Inhibition Anti-aging

Science

Mechanism of Action

This ingredient functions by decreasing the overproduction of Nerve Growth Factor (NGF) and the TRPV1 receptor, key contributors to skin sensitivity, thereby alleviating discomfort. It significantly strengthens the skin's barrier by promoting epidermal thickening and stimulating the synthesis of occludin, a critical protein for tight junction cohesion. Furthermore, it demonstrates potent antioxidant activity by scavenging free radicals, possesses anti-inflammatory properties, inhibits tyrosinase activity to reduce melanin synthesis, and mitigates elastase activity while up-regulating anti-aging protein expression to support dermal collagen regulation.

Research

Clinical Evidence

Medium confidence
Effective range 0.00015–1.5%
Optimal

N/A

Key findings

  1. 01 Clinical investigations using Mirabilis jalapa extract, at concentrations ranging from 0.00015% to 1.5% (referring to the dry residue), have shown efficacy in reducing overactive Nerve Growth Factor (NGF) and TRPV1 receptor signaling. This action directly contributes to decreased skin sensitivity, alongside observed benefits such as epidermal thickening and improved stratum corneum barrier function.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

While the optimal pH for Mirabilis jalapa callus culture growth is cited as 5.7 ± 0.1, specific stability data for the powder form within cosmetic formulations is not comprehensively detailed.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

Comprehensive safety evaluations by CIR, SCCS, or FDA specifically for Mirabilis Jalapa Callus Powder are currently limited. The CIR has noted challenges with 'callus culture extract' ingredients from other plants due to insufficient data, suggesting a similar scenario here. However, general Mirabilis jalapa extract is generally associated with a low risk of irritation.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While Mirabilis jalapa extract demonstrates compelling benefits for sensitive skin, barrier health, and anti-aging, specific clinical efficacy and safety data pertaining solely to the callus powder form remain insufficient for a definitive rating.

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