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Moumoujus

MIRABILIS JALAPA CALLUS EXTRACT.

Valuable CAS 91722-88-2 / SKIN PROTECTING

Mirabilis Jalapa Callus Extract is a multi-functional botanical ingredient recognized for its profound effects on skin sensitivity, barrier integrity, and anti-aging. It precisely targets discomfort by modulating neural pathways while simultaneously strengthening the skin's inherent protective mechanisms and combating signs of aging and oxidative stress.

Summary

soothing anti-inflammatory antioxidant skin-identical ingredient barrier strengthening collagen boosting skin tone evening antimicrobial anti-aging

Science

Mechanism of Action

Mirabilis Jalapa Callus Extract modulates key mediators of skin discomfort by reducing the overproduction of Nerve Growth Factor (NGF) and the TRPV1 receptor, thereby alleviating sensations like stinging and itching associated with sensitive skin. It reinforces the skin barrier by promoting epidermal thickening, stimulating the synthesis of occludin (a tight junction protein), and enhancing ceramide production within the stratum corneum. Beyond barrier support, it acts as a potent antioxidant, neutralizing free radicals, and exhibits anti-aging properties by inhibiting tyrosinase and elastase activity, alongside up-regulating proteins crucial for collagen synthesis. The extract also contributes anti-inflammatory and antimicrobial benefits to skin health.

Research

Clinical Evidence

High confidence
Effective range 0.00015–1.5%
Optimal

N/A

Key findings

  1. 01 Clinical evaluations using a dry residue extract of Mirabilis jalapa, across a concentration range of 0.00015% to 1.5%, demonstrated significant efficacy in treating sensitive skin. This involved a measurable reduction in the overproduction of Nerve Growth Factor (NGF) and TRPV1 receptor activity, thickening of the epidermis, and notable improvements in stratum corneum barrier function through stimulated occludin and ceramide synthesis.
  2. 02 Further studies on Mirabilis jalapa L. extracts, particularly from the flower, reveal potent antioxidant capabilities via free radical scavenging. The extract also displayed anti-aging effects by inhibiting tyrosinase and elastase activity, alongside the up-regulation of anti-aging protein expression in human fibroblasts, contributing to enhanced collagen production.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.00015%
Red flag below
0.00015%

While effective concentrations extend up to 1.5%, the documented efficacy at concentrations as low as 0.00015% indicates a potential for this ingredient to be present in formulations at insufficient levels to deliver its full spectrum of benefits. Moumoujus prioritizes transparency and optimal ingredient concentrations for visible results.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The selection of excipients should meticulously consider the extract's stability and solubility to maintain optimal efficacy.

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1.5%
Sensitization risk Low

Generally considered safe for topical cosmetic application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Mirabilis Jalapa Callus Extract is a valuable ingredient for its comprehensive ability to soothe sensitive skin, reinforce the epidermal barrier, and deliver robust anti-aging and antioxidant benefits.

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