Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

METHYLTHIOADENOSINE.

Valuable CAS 2457-80-9 / SKIN CONDITIONING

Methylthioadenosine (MTA) is a sulfur-donating molecule essential for robust skin structure, aiding in the formation of critical disulfide bonds that maintain firmness and elasticity. Beyond its structural role in keratinization, it demonstrates protective and anti-inflammatory properties, particularly beneficial for delicate and reactive skin types.

Summary

Anti-inflammatory Skin barrier support Firming Elasticity enhancer Soothing Melanin regulation Scalp conditioning

Science

Mechanism of Action

Methylthioadenosine (MTA) functions by supplying sulfur, a vital component for the formation of sulfhydryl (SH) groups and disulfide (S-S) bonds within skin tissues. These bonds are indispensable for preserving the skin's structural integrity, contributing directly to its firmness, elasticity, and overall balance, and are integral to the epidermal keratinization process. Additionally, MTA exerts anti-inflammatory and protective effects, mitigating inflammatory responses, and modulates cellular processes such as gene expression, proliferation, differentiation, and apoptosis.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

MTA is provided as a crystalline solid, exhibiting solubility in both organic solvents (e.g., DMSO 20-100 mg/mL, dimethyl formamide 5 mg/mL) and aqueous buffers (e.g., PBS pH 7.2 at approximately 10 mg/mL). Stock solutions prepared in organic solvents maintain stability for up to one month when stored at -20°C, whereas aqueous solutions are not recommended for storage for more than one day.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

An epicutaneous patch test conducted on 25 healthy volunteers demonstrated no detectable pro-sensitizing effects for MTA. Its recommended application in topical formulations targeting delicate, sensitive, easily reddened, and irritable skin further supports a favorable safety profile for these compromised conditions.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Methylthioadenosine offers valuable multi-faceted benefits, enhancing skin structure and elasticity while providing significant soothing and protective actions for sensitive and compromised skin.

Related

Similar Ingredients

Finding similar ingredients…