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METHYLSALICYLATYL GLYCYRRHETINATE.

Insufficient Data CAS 1417626-01-7 / SKIN CONDITIONING

Methylsalicylatyl Glycyrrhetinate is an ester formed by combining Methyl Salicylate and Glycyrrhetinic Acid, a compound derived from licorice root. It is designed to offer potent anti-inflammatory, soothing, and antioxidant benefits to the skin.

Summary

Skin Conditioning Anti-inflammatory Soothing Antioxidant Barrier Support Skin Brightening

Science

Mechanism of Action

This compound primarily acts through its Glycyrrhetinic Acid component, which is recognized for its significant anti-inflammatory and soothing properties, helping to mitigate redness and sensitivity. It also functions as an antioxidant, safeguarding skin cells from free radical damage, and contributes to strengthening the skin's natural barrier by retaining moisture. Additionally, it can support an even skin tone by assisting in the reduction of hyperpigmentation. The Methyl Salicylate component also contributes a soothing effect, alongside its roles as a denaturant and perfuming agent.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Methylsalicylatyl Glycyrrhetinate is anticipated to be oil-soluble, similar to related glycyrrhetinate esters. Emulsions containing Glycyrrhetinic acid have shown phase separation at very low pH values (specifically 2 and 3), indicating potential instability in highly acidic formulations. If sourced from botanicals, diligent testing for pesticide and heavy metal residues is crucial to ensure product purity and safety.

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Unknown

Direct safety data for Methylsalicylatyl Glycyrrhetinate is currently insufficient as it has not been specifically reviewed by CIR or SCCS. However, its components and related compounds offer context: Glycyrrhetinic Acid and its esters, such as Stearyl Glycyrrhetinate, have been deemed safe by the CIR Expert Panel for cosmetic use at concentrations up to 2% and 1% respectively, without being classified as irritants, sensitizers, phototoxic, or photosensitizing agents. Methyl Salicylate has SCCS-determined safe maximum concentrations, including 6% as a UV-filter, 0.5% for product protection in cosmetics, and 0.1% in mouthwashes for children under 10.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While its foundational components suggest promising skin benefits, direct clinical efficacy and safety data for Methylsalicylatyl Glycyrrhetinate itself are currently insufficient, warranting further research.

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